相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice
Andre-Guilhem Calas et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2017)
Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and apoptotic events
Alessandra Antunes dos Santos et al.
ARCHIVES OF TOXICOLOGY (2016)
Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase
Elaine da Conceicao Petronilho et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2016)
Learning performances and vulnerability to amyloid toxicity in the butyrylcholinesterase knockout mouse
Tangui Maurice et al.
BEHAVIOURAL BRAIN RESEARCH (2016)
Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents
C. Linn Cadieux et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2016)
Development and validation of a FIA/UV-vis method for pKa determination of oxime based acetylcholinesterase reactivators
Karel Musil et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2016)
Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6
Anders Allgardsson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase
Michael Winter et al.
TOXICOLOGY LETTERS (2016)
Kinetic analysis of interactions of amodiaquine with human cholinesterases and organophosphorus compounds
Anne Bierwisch et al.
TOXICOLOGY LETTERS (2016)
A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication
E. Nepovimova et al.
TOXICOLOGY RESEARCH (2016)
Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE)
Aditya Kapil Valiveti et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates
Francine S. Katz et al.
CHEMBIOCHEM (2015)
Synthesis and in vitro kinetic study of novel mono-pyridinium oximes as reactivators of organophosphorus (OP) inhibited human acetylcholinesterase (hAChE)
Aditya Kapil Valiveti et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2015)
Coumarins: Auspicious Cholinesterase and Monoamine Oxidase Inhibitors
Ilkay Erdogan Orhan et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2015)
Discovery of non-oxime reactivators using an in silico pharmacophore model of reactivators for DFP-inhibited acetylcholinesterase
Apurba K. Bhattacharjee et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase
Rafael Dolezal et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2015)
Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review
Rahul Sharma et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2015)
Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses
Oksana Lockridge
PHARMACOLOGY & THERAPEUTICS (2015)
Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase
Gabriele Horn et al.
ARCHIVES OF TOXICOLOGY (2015)
Oxime-dipeptides as anticholinesterase, reactivator of phosphonylated-serine of AChE catalytic triad: probing the mechanistic insight by MM-GBSA, dynamics simulations and DFT analysis
Nidhi Chadha et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2015)
In vitro reactivation kinetics of paraoxon- and DFP-inhibited electric eel AChE using mono- and bis-pyridinium oximes
Bhanushree Gupta et al.
ARCHIVES OF TOXICOLOGY (2014)
Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE)
Hitendra N. Karade et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase
Stanton F. McHardy et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase
Zhao Wei et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases
Julien Renou et al.
CHEMICAL COMMUNICATIONS (2014)
Quantum chemical and steered molecular dynamics studies for one pot solution to reactivate aged acetylcholinesterase with alkylator oxime
Nellore Bhanu Chandar et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2014)
Current Acetylcholinesterase-Inhibitors: A Neuroinformatics Perspective
Sibhghatulla Shaikh et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2014)
Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase
Maria Kliachyna et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
ZnII/pyridyloxime complexes as potential reactivators of OP-inhibited acetylcholinesterase: In vitro and docking simulation studies
Konstantis F. Konidaris et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2014)
Imidazole Aldoximes Effective in Assisting Butyrylcholinesterase Catalysis of Organophosphate Detoxification
Rakesh K. Sit et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators
Jan Korabecny et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2014)
Can hydroxylamine be a more potent nucleophile for the reactivation of tabun-inhibited AChE than prototype oxime drugs? An answer derived from quantum chemical and steered molecular dynamics studies
Rabindranath Lo et al.
MOLECULAR BIOSYSTEMS (2014)
Interactions between xylene-linked carbamoyl bis-pyridinium mono-oximes and organophosphates inhibited-AChE: A kinetic study
Rahul Sharma et al.
TOXICOLOGY (2014)
The Use of Chemical Weapons in the Syrian Conflict
Rene Pita et al.
TOXICS (2014)
Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine
Filip Zemek et al.
EXPERT OPINION ON DRUG SAFETY (2014)
The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors
O. Soukup et al.
ARCHIVES OF TOXICOLOGY (2013)
Quantitative structure-activity relationships for organophosphates binding to acetylcholinesterase
Christopher D. Ruark et al.
ARCHIVES OF TOXICOLOGY (2013)
A physiologically based pharmacokinetic model for the oxime TMB-4: simulation of rodent and human data
Teresa R. Sterner et al.
ARCHIVES OF TOXICOLOGY (2013)
Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes
Zoran Radic et al.
BIOCHEMICAL JOURNAL (2013)
A step toward the reactivation of aged cholinesterases - Crystal structure of ligands binding to aged human butyrylcholinesterase
Marielle Wandhammer et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2013)
Centrally acting oximes in reactivation of tabun-phosphoramidated AChE
Zrinka Kovarik et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2013)
Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents
Julien Renou et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2013)
Progress in the development of enzyme-based nerve agent bioscavengers
Florian Nachon et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2013)
Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates
Janice E. Chambers et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2013)
A Resurrection of 7-MEOTA: A Comparison with Tacrine
Ondrej Soukup et al.
Current Alzheimer Research (2013)
Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection
Manjinder Singh et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Structure-Based Search for New Inhibitors of Cholinesterases
Marek Bajda et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)
Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma
Jana Zdarova Karasova et al.
JOURNAL OF APPLIED TOXICOLOGY (2013)
Kinetic Assessment of N-Methyl-2-methoxypyridinium Species as Phosphonate Anion Methylating Agents
Joseph J. Topczewski et al.
ORGANIC LETTERS (2013)
The value of novel oximes for treatment of poisoning by organophosphorus compounds
Franz Worek et al.
PHARMACOLOGY & THERAPEUTICS (2013)
Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents
Guillaume Mercey et al.
ACCOUNTS OF CHEMICAL RESEARCH (2012)
Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease
Yun Suk Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Prospective acetylcholinesterase inhibitory activity of indole and its analogs
Nantaka Khorana et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Structure-Activity Relationship and Efficacy of Pyridinium Oximes in the Treatment of Poisoning with Organophosphorus Compounds: A Review of Recent Data
Milan Jokanovic
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)
Discovery of non-oxime reactivators using an in silico pharmacophore model of oxime reactivators of OP-inhibited acetylcholinesterase
Apurba K. Bhattacharjee et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
Zoran Radic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Nonquaternary Reactivators for Organophosphate-Inhibited Cholinesterases
Jaroslaw Kalisiak et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Phenyltetrahydroisoquinoline-Pyridinaldoxime Conjugates as Efficient Uncharged Reactivators for the Dephosphylation of Inhibited Human Acetylcholinesterase
Guillaume Mercey et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Mechanistic insights into the hydrolysis of organophosphorus compounds by paraoxonase-1: exploring the limits of substrate tolerance in a promiscuous enzyme
Sivaramakrishnan Muthukrishnan et al.
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY (2012)
Synthesis and In Vitro and In Vivo Inhibition Potencies of Highly Relevant Nerve Agent Surrogates
Edward C. Meek et al.
TOXICOLOGICAL SCIENCES (2012)
The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers
O. Soukup et al.
TOXICOLOGY LETTERS (2012)
Retinal Toxicity Associated With Hydroxychloroquine and Chloroquine Risk Factors, Screening, and Progression Despite Cessation of Therapy
Michel Michaelides et al.
ARCHIVES OF OPHTHALMOLOGY (2011)
Peripheral site ligand-oxime conjugates: A novel concept towards reactivation of nerve agent-inhibited human acetylcholinesterase
M. C. de Koning et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase
Guillaume Mercey et al.
CHEMICAL COMMUNICATIONS (2011)
The effect of oxime reactivators on muscarinic receptors: Functional and binding examinations
O. Soukup et al.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2011)
Synthesis and in vitro evaluation of xylene linked carbamoyl bis-pyridinium monooximes as reactivators of organophosphorus (OP) inhibited electric eel acetylcholinesterase (AChE)
Jyotiranjan Acharya et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
Rakesh K. Sit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning
Christopher M. Timperley et al.
JOURNAL OF FLUORINE CHEMISTRY (2011)
Amidine-Oximes: Reactivators for Organophosphate Exposure
Jaroslaw Kalisiak et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Active Site Gating and Substrate Specificity of Butyrylcholinesterase and Acetylcholinesterase: Insights from Molecular Dynamics Simulations
Lei Fang et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2011)
Targeting Acetylcholinesterase: Identification of Chemical Leads by High Throughput Screening, Structure Determination and Molecular Modeling
Lotta Berg et al.
PLOS ONE (2011)
Design, synthesis and evaluation of new α-nucleophiles for the hydrolysis of organophosphorus nerve agents: application to the reactivation of phosphorylated acetylcholinesterase
Geraldine Saint-Andre et al.
TETRAHEDRON (2011)
Peripheral site ligand conjugation to a non-quaternary oxime enhances reactivation of nerve agent-inhibited human acetylcholinesterase
Martijn C. de Koning et al.
TOXICOLOGY LETTERS (2011)
Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties
Travis T. Wager et al.
ACS CHEMICAL NEUROSCIENCE (2010)
In Silico Pharmacophore Model for Tabun-Inhibited Acetylcholinesterase Reactivators: A Study of Their Stereoelectronic Properties
Apurba K. Bhattacharjee et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2010)
Reactivation of brain acetylcholinesterase by monoisonitrosoacetone increases the therapeutic efficacy against nerve agents in guinea pigs
Jacob W. Skovira et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Novel oximes as blood-brain barrier penetrating cholinesterase reactivators
Gregory E. Garcia et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Structural approach to the aging of phosphylated cholinesterases
Patrick Masson et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Pseudo-catalytic scavenging: Searching for a suitable reactivator of phosphorylated butyrylcholinesterase
Zrinka Kovarik et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
A HTS Assay for the Detection of Organophosphorus Nerve Agent Scavengers
Ludivine Louise-Leriche et al.
CHEMISTRY-A EUROPEAN JOURNAL (2010)
Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies
Kamil Musilek et al.
CHEMMEDCHEM (2010)
Structure-Activity Relationship of Quaternary Acetylcholinesterase Inhibitors - Outlook for Early Myasthenia Gravis Treatment
M. Komloova et al.
CURRENT MEDICINAL CHEMISTRY (2010)
A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice
Jiri Kassa et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2010)
Structural Evidence That Human Acetylcholinesterase Inhibited by Tabun Ages through O-Dealkylation
Eugenie Carletti et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Treatment with Tertiary Oximes Prevents Seizures and Improves Survival Following Sarin Intoxication
Tsung-Ming Shih et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2010)
Tau protein and tau aggregation inhibitors
Bruno Bulic et al.
NEUROPHARMACOLOGY (2010)
In vitro evaluation of bis-pyridinium oximes bearing methoxy alkane linker as reactivators of sarin inhibited human acetylcholinesterase
Jyotiranjan Acharya et al.
TOXICOLOGY IN VITRO (2010)
Effects of 4-pyridine aldoxime on nerve agent-inhibited acetylcholinesterase activity in guinea pigs
Tsung-Ming Shih et al.
ARCHIVES OF TOXICOLOGY (2009)
Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun
Eugenie Carletti et al.
BIOCHEMICAL JOURNAL (2009)
REACTIVATION POTENCY OF THE ACETYLCHOLINESTERASE REACTIVATOR OBIDOXIME IS LIMITED
Kamil Kuca et al.
BIOMEDICAL PAPERS-OLOMOUC (2009)
Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent
Hee Chun Jeong et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Reactivation potency of fluorinated pyridinium oximes for acetylcholinesterases inhibited by paraoxon organophosphorus agent
Hee Chun Jeong et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Chemical Synthesis of Two Series of Nerve Agent Model Compounds and Their Stereoselective Interaction with Human Acetylcholinesterase and Human Butyrylcholinesterase
Nora H. Barakat et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2009)
Nerve Agent Analogues That Produce Authentic Soman, Sarin, Tabun, and Cyclohexyl Methylphosphonate-Modified Human Butyrylcholinesterase
Cynthia Gilley et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2009)
Synthesis and evaluation of novel bis-pyridinium oximes as reactivators of DFP-inhibited acetylcholinesterase
Jyotiranjan Acharya et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2009)
In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker
Jyotiranjan Acharya et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2009)
Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime
Benoit Sanson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Nucleophilic Reactivation of Sarin-Inhibited Acetylcholinesterase: A Molecular Modeling Study
Reinaldo T. Delfino et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2009)
Structure of HI-6•Sarin-Acetylcholinesterase Determined by X-Ray Crystallography and Molecular Dynamics Simulation: Reactivator Mechanism and Design
Fredrik Ekstrom et al.
PLOS ONE (2009)
Dinuclear versus trinuclear complex formation in zinc(II) benzoate/pyridyl oxime chemistry depending on the position of the oxime group
Konstantis F. Konidaris et al.
POLYHEDRON (2009)
Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis
Elisabet Artursson et al.
TOXICOLOGY (2009)
Management of acute organophosphorus pesticide poisoning
Michael Eddleston et al.
LANCET (2008)
In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages
Jyotiranjan Acharya et al.
TOXICOLOGY IN VITRO (2008)
Preparation and characterization of dialkylphosphoryl-obidoxime conjugates, potent anticholinesterase derivatives that are quickly hydrolyzed by human paraoxonase (PON1192Q)
J. Stenzel et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Design of a potent reactivator of tabun-inhibited acetyleholinesterase-synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203)
Kamil Musilek et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Aβ1-42 aggregation for Alzheimer's disease therapeutics
Young Ee Kwon et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Treatment of organophosphate intoxication using cholinesterase reactivators: Facts and fiction
Jiri Bajgar et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2007)
Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis
F. Worek et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2007)
Changes of acetylcholinesterase activity in different rat brain areas following intoxication with nerve agents: Biochemical and histochemical study
Jiri Bajgar et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2007)
Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates
Franz Worek et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Unequal Efficacy of Pyridinium Oximes in Acute Organophosphate Poisoning
Biljana Antonijevic et al.
CLINICAL MEDICINE & RESEARCH (2007)
Progress in synthesis of new acetylcholinesterase reactivators during the period 1990-2004
K. Musilek et al.
CURRENT ORGANIC CHEMISTRY (2007)
New safe method for preparation of sarin-exposed human erythrocytes acetylcholinesterase using non-toxic and stable sarin analogue isopropyl p-nitrophenyl methylphosphonate and its application to evaluation of nerve agent antidotes
Hikoto Ohta et al.
PHARMACEUTICAL RESEARCH (2006)
Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX
Kyung-Ae Oh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase:: Binding of bis(5)-tacrine produces a dramatic rearrangement in the active-site gorge
Edwin H. Rydberg et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Quaternary salts of 4,3′ and 4,4′ bis-pyridinium monooximes.: Part 2:: Synthesis and biological activity
CS Rao et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor
JP Colletier et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Structural requirements of acetylcholinesterase reactivators
K Kuca et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2006)
Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents
L Briseño-Roa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
The peripheral anionic site of acetylcholinesterase: Structure, functions and potential role in rational drug design
G Johnson et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Acetylcholinesterase: Molecular modeling with the whole toolkit
GH Lushington et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE
D Alonso et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors:: New disease-modifying agents for Alzheimer's disease
P Muñoz-Ruiz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Effective bisquaternary reactivators of tabun-inhibited AChE
K Kuca et al.
JOURNAL OF APPLIED TOXICOLOGY (2005)
Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase
K Musilek et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2005)
Formation and disposition of diethylphosphoryl-obidoxime, a potent anticholinesterase that is hydrolyzed by human paraoxonase (PON1)
D Kiderlen et al.
BIOCHEMICAL PHARMACOLOGY (2005)
Quaternary salts of 4,3′ and 4,4′ bis-pyridinium monooximes:: Synthesis and biological activity
SR Chennamaneni et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Design and synthesis of new bis-pyridinium oxime reactivators for acetyleholinesterase inhibited by organophosphorous nerve agents
TH Kim et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
In situ selection of lead compounds by click chemistry: Target-guided optimization of acetylcholinesterase inhibitors
A Krasinski et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates
Z Kovarik et al.
BIOCHEMISTRY (2004)
Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes
F Worek et al.
BIOCHEMICAL PHARMACOLOGY (2004)
The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs
JE Kipp
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2004)
Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase
K Kuca et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Pralidoxime iodide (2-PAM) penetrates across the blood-brain barrier
K Sakurada et al.
NEUROCHEMICAL RESEARCH (2003)
Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase
CY Luo et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators
Y Ashani et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Retrospective detection of exposure to organophosphorus anti-cholinesterases: Mass spectrometric analysis of phosphylated human butyrylcholinesterase
A Fidder et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2002)
Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents
J Kassa
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY (2002)
Stereoselective detoxification of chiral sarin and soman analogues by phosphotriesterase
WS Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2001)
Intensive care management of organophosphate insecticide poisoning
M Sungur et al.
CRITICAL CARE (2001)
Toward antibody-catalyzed hydrolysis of organophosphorus poisons
P Vayron et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis
L Wong et al.
BIOCHEMISTRY (2000)
Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase
F Worek et al.
ARCHIVES OF TOXICOLOGY (2000)