期刊
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
卷 97, 期 1, 页码 45-52出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.apmr.2015.08.423
关键词
Aged; Motor neurons; Peripheral nerves; Physical endurance; Rehabilitation; Sensation; Walking
资金
- National Institute on Aging [N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106, 1-R01-AG 028050]
- National Institute of Nursing Research [R01-NR012459]
- University of Pittsburgh Claude D. Pepper Older Americans Independence Center [P30-AG024827]
- National Institutes of Health, National Institute on Aging
- NATIONAL INSTITUTE OF NURSING RESEARCH [R01NR012459] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [N01AG062106, P30AG024827, N01AG062103, N01AG062101, R01AG028050] Funding Source: NIH RePORTER
Objectives: To determine whether lower extremity sensorimotor peripheral nerve deficits are associated with reduced walking endurance in older adults. Design: Prospective cohort study with 6 years of follow-up. Setting: Two university research clinics. Participants: Community-dwelling older adults enrolled in the Health, Aging and Body Composition Study from the 2000-2001 annual clinical examination (N=2393; mean age +/- SD, 76.5 +/- 2.9y; 48.2% men; 38.2% black) and a subset with longitudinal data (n=1178). Interventions: Not applicable. Main Outcome Measures: Participants underwent peripheral nerve function examination in 2000-2001, including peroneal motor nerve conduction amplitude and velocity, vibration perception threshold, and monofilament testing. Symptoms of lower extremity peripheral neuropathy included numbness or tingling and sudden stabbing, burning, pain, or aches in the feet or legs. The Long Distance Corridor Walk (LDCW) (400m) was administered in 2000-2001 and every 2 years afterward for 6 years to assess endurance walking performance over time. Results: In separate, fully adjusted linear mixed models, poor vibration threshold (>130 mu m), 10-g and 1.4-g monofilament insensitivity were each associated with a slower 400-m walk completion time (16.0s, 14.4s, and 6.9s slower, respectively; P<.05 for each). Poor motor amplitude (<1mV), poor vibration perception threshold, and 10-g monofilament insensitivity were related to greater slowing per year (4.7, 4.2, and 3.8 additional seconds per year, respectively; P<.05), although poor motor amplitude was not associated with initial completion time. Conclusions: Poorer sensorimotor peripheral nerve function is related to slower endurance walking and greater slowing longitudinally. Interventions to reduce the burden of sensorimotor peripheral nerve function impairments should be considered to help older adults maintain walking endurance-a critical component for remaining independent in the community. (C) 2016 by the American Congress of Rehabilitation Medicine
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