期刊
ONCOIMMUNOLOGY
卷 8, 期 10, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2019.1633235
关键词
Metformin; immunotherapy; T-cells; immune checkpoints
资金
- Spanish Ministry of Science and Innovation [SAF2016-80639-P]
- Fundacio Oncolliga Girona (Lliga catalana d'ajuda al malalt de cancer, Girona)
The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacologically implausible. Metformin might help solve this conundrum and beneficially impact the state of cancer-immune system interactions.
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