期刊
MATERIALS RESEARCH EXPRESS
卷 6, 期 9, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/2053-1591/ab2b6b
关键词
economical synthesis; ultra-small nanoparticles; Bi2S3; high-sensitive; CT imaging
资金
- National Natural Science Foundation of China [21375100, 81472033, 21535005, 30901308]
- Natural Science Foundation of Hubei Province [2014CFA003]
- Health Commission of Hubei Province Scientific Research Project [WJ2019M203]
- Application Basic Research Plan Program of Wuhan City [2017060201010171]
- Joint Fund Project of Hubei Health and Family Planning Commission [WJ2018H0028]
Ultra-small Bi2S3 nanoparticles are potential contrast agents for high-sensitive CT imaging. However, the expensive and harmful synthesis process limited their further application. Herein, an economical and low-toxic process was developed by employing S powders as sulfur precursors for large-scale preparation of ultra-small Bi2S3 nanoparticles. The as-prepared ultra-small Bi2S3 nanoparticles were modified with amine-terminated poly(ethylene glycol) (PEG) to produce water-soluble contrast agents. In vitro experiment results suggested that the ultra-small Bi2S3-PEG nanoparticles were low cytotoxic and superior contrast agents. In vivo experiments demonstrated that the ultra-small Bi2S3-PEG nanoparticles were preferred contrast agents for long-term and high-sensitive CT imaging.
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