期刊
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
卷 97, 期 4, 页码 650-654出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.apmr.2015.12.010
关键词
Nervous system diseases; Patient outcome assessment; Psychometrics; Quality of life; Rehabilitation
资金
- National Institute of Neurological Disorders and Stroke [HHSN265200423601C]
- National Institute on Disability and Rehabilitation Research [H133B090024]
Objective: To provide a clinically useful means of interpreting change for individual patients on the Quality of Life in Neurological Disorders (Neuro-QoL) adult short forms (SFs) by applying a classical test theory concept for interpreting individual change. Design: Secondary analysis of existing data. Setting: Community. Participants: Persons with neurologic conditions including stroke, epilepsy, amyotrophic lateral sclerosis, multiple sclerosis, and Parkinson disease residing in community settings. Interventions: Not applicable. Main Outcome Measures: Neuro-QoL SFs for Applied Cognition General Concerns, Applied Cognition Executive Function, Applied Cognition Combined, Ability to Participate in Social Roles and Activities, Satisfaction With Social Roles and Activities, Positive Affect and Well-Being, Depression, Stigma, Upper Extremity Function (Fine Motor, Activities of Daily Living), Lower Extremity Function (Mobility), Anxiety, Sleep Disturbance, Fatigue, and Emotional and Behavioral Dyscontrol. We estimated conditional minimal detectable change (cMDC) indices from the pooled SEs adjusted for a 95% confidence interval using the average of the SEs for any given pair of scores multiplied by the z score, or ([SEScore1 + SEScore2]/2) * (1.96) * (SQRT(2)). Results: The cMDC indices are generally smallest in the midrange of all scales, ranging from 3.6 to 11.2 T-score points, and higher on the outer quartiles ranging from 3.7 to 21.6 T-score points. The lowest midrange cMDCs were for Satisfaction With Social Roles and Activities (3.6-4.7 T-score points), and the largest were for Sleep Disturbance (9.4-11.2 T-score points). Conclusions: Change indices can help clinicians and investigators identify differences for individual patients or subjects that are large enough to motivate treatment change. cMDCs can reduce misclassification of magnitudes of change that are near the margins of error across the range of the Neuro-QoL SFs. (C) 2016 by the American Congress of Rehabilitation Medicine
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