4.5 Article

Novel multi-layer silica aerogel/PVA composite for controlled drug delivery

期刊

MATERIALS RESEARCH EXPRESS
卷 6, 期 9, 页码 -

出版社

IOP PUBLISHING LTD
DOI: 10.1088/2053-1591/ab3097

关键词

silica aerogel; nano fiber; polyvinyl alcohol; controlled drug delivery; fluconazole

向作者/读者索取更多资源

A novel multi-layer composite (MLC) was developed consisting of a polyvinyl alcohol (PVA) film as a substrate and a drug loaded silica aerogel powder which coated by PVA nano fibers. It was tested as a controlled drug delivery system (DDS) with fluconazole as an anti-fungal drug. The hydrophilic and hydrophobic silica aerogels synthesized at ambient pressure and loaded with the fluconazole. Results of drug release showed that silica aerogels have a faster release rather than pure fluconazole because of a high specific surface area (> 800 m(2) g(-1)) and high porosity (> 80%). Release rate of about 80% of the fluconazole loaded in the hydrophilic and hydrophobic silica aerogels showed an increase of 3.7-fold and 2.5-fold compare to the crystalline form of the drug, respectively. Furthermore, the PVA nano fibers help to control the fluconazole release rate. The silica aerogel/PVA composites exhibited the non-Fickian mechanism for the drug release while, the loaded silica aerogel powders follow the Fickian mechanism. The composite contains hydrophilic silica aerogel showed stronger effect on the controlled drug release compare to the hydrophobic sample. The results of the anti-fungal properties showed that the drug loaded samples have a good consequence on the fungal.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据