期刊
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
卷 97, 期 4, 页码 513-521出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.apmr.2015.10.103
关键词
Accidental falls; Multiple sclerosis; Posture; Rehabilitation
资金
- National Multiple Sclerosis Society [RG 4914A1/2]
- National Institutes of Health, National Center for Advancing Translational Science [1KL2TR000119]
- United States Department of Veterans Affairs Rehabilitation Research and Development Service [I01BX007080]
- Medical Research Foundation of Oregon (Early Investigator Award)
- Veterans Affairs Merit Award [E1075-R]
- National Institutes of Health [R01 AG006457 29]
Objective: To characterize postural responses to forward and backward external perturbations in people with multiple sclerosis (PwMS), and to relate performance to commonly used clinical outcomes. Design: Cross-sectional study. Postural responses were tested during large stepping and smaller feet-in-place perturbations in forward and backward directions. Setting: University research laboratory. Participants: PwMS (n=54) and age-matched controls (n=21) (N=75). Interventions: Not applicable. Main Outcome Measures: Center of mass displacement and step latency after external perturbations. Results: PwMS exhibited larger center of mass displacements and step latencies than control participants in response to stepping perturbations (P=.003 and P=.028, respectively). Stepping deficits were more pronounced during backward stepping and were significantly correlated to increased severity on clinical measures (European Database for Multiple Sclerosis disability score and Timed 25-Foot Walk). Conclusions: Compensatory stepping is impaired in PwMS and correlates with clinical disability. Measurement of backward compensatory stepping may be more effective at identifying postural dysfunction in PwMS than forward compensatory steps. Prolonged step latencies, large anticipatory postural adjustments, and multiple compensatory steps are especially altered in PwMS, suggesting possible targets for neurorehabilitation. (C) 2016 by the American Congress of Rehabilitation Medicine
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