期刊
FRONTIERS IN IMMUNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01751
关键词
MARCH proteins; E3 ligase; ubiquitination; immune regulation; immune receptors
类别
资金
- Ministry of Science and Technology of China [2017YFA0505800, 2016YFA0502102]
- National Natural Science Foundation of China [31630045, 31830024, 31671465, 31871415]
- National Postdoctoral Programfor Innovative Talents [BX20190255]
The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases have emerged as critical regulators of immune responses. MARCH proteins target immune receptors, viral proteins as well as components in innate immune response for polyubiquitination and degradations via distinct routes. This review summarizes the current progress about MARCH proteins and their regulation on immune responses.
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