相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Safety and Tolerability of Adoptive Cell Therapy in Cancer
Benita Wolf et al.
DRUG SAFETY (2019)
Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer
Mohammad H. Kazemi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2018)
cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes
Timothy B. Johnstone et al.
MOLECULAR PHARMACOLOGY (2018)
A2B adenosine receptor agonist induces cell cycle arrest and apoptosis in breast cancer stem cells via ERK1/2 phosphorylation
Seyyed Mehdi Jafari et al.
CELLULAR ONCOLOGY (2018)
Consensus guidelines for the use and interpretation of angiogenesis assays
Patrycja Nowak-Sliwinska et al.
ANGIOGENESIS (2018)
Comprehensive evaluation of NT5E/CD73 expression and its prognostic significance in distinct types of cancers
Tao Jiang et al.
BMC CANCER (2018)
Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models
Robert D. Leone et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)
Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer
Lifeng Li et al.
CANCER RESEARCH (2018)
Autocrine Adenosine Regulates Tumor Polyfunctional CD73(+)CD4(+) Effector T Cells Devoid of Immune Checkpoints
Nicolas Gourdin et al.
CANCER RESEARCH (2018)
AB928, a dual antagonist of the A 2a R and A 2b R adenosine receptors, leads to greater immune activation and reduced tumor growth when combined with chemotherapy
U. Schindler et al.
EUROPEAN JOURNAL OF CANCER (2018)
The Inside Story of Adenosine
Marcella Camici et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
A2A Adenosine Receptor Gene Deletion or Synthetic A2A Antagonist Liberate Tumor-Reactive CD8+ T Cells from Tumor-Induced Immunosuppression
Jorgen Kjaergaard et al.
JOURNAL OF IMMUNOLOGY (2018)
Extracellular adenosine produced by ecto-5′-nucleotidase (CD73) regulates macrophage pro-inflammatory responses, nitric oxide production, and favors Salmonella persistence
Matthew G. Costales et al.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)
Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells
Debangshu Samanta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging
Eduardo N. Chini et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2018)
CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade
Limo Chen et al.
CANCER DISCOVERY (2018)
CD73 expression and clinical significance in human metastatic melanoma
Inês Monteiro et al.
Oncotarget (2018)
Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors
Sonja Hinz et al.
Oncotarget (2018)
Emerging Roles of Nucleoside Transporters
Marcal Pastor-Anglada et al.
FRONTIERS IN PHARMACOLOGY (2018)
Who Is Who in Adenosine Transport
Marcal Pastor-Anglada et al.
FRONTIERS IN PHARMACOLOGY (2018)
Targeting adenosine for cancer immunotherapy
Robert D. Leone et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)
Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, efficacy, and Limitations
Judith A. Seidel et al.
FRONTIERS IN ONCOLOGY (2018)
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Yannick Simoni et al.
NATURE (2018)
In Vivo Expansion of Regulatory T Cells with IL-2/IL-2 Antibody Complex Protects against Transient Ischemic Stroke
Haiyue Zhang et al.
JOURNAL OF NEUROSCIENCE (2018)
Extracellular ATP and P2 purinergic signalling in the tumour microenvironment
Francesco Di Virgilio et al.
NATURE REVIEWS CANCER (2018)
CD38 knockout suppresses tumorigenesis in mice and clonogenic growth of human lung cancer cells
Xiangning Bu et al.
CARCINOGENESIS (2018)
Adenosine generation limits the ability of radiation therapy to induce antitumor immunity by abrogating recruitment and activation of CD103+DCs
Erik Wennerberg et al.
CANCER IMMUNOLOGY RESEARCH (2018)
A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment
Arabella Young et al.
CANCER RESEARCH (2018)
CD4 and CD8 T lymphocyte interplay in controlling tumor growth
Dmitrij Ostroumov et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2018)
CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8(+) T Cells
Fernando P. Canale et al.
CANCER RESEARCH (2018)
Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer
S. R. Rao et al.
BRITISH JOURNAL OF CANCER (2017)
Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases
Bruce N. Cronstein et al.
NATURE REVIEWS RHEUMATOLOGY (2017)
Adenosine A2A receptor regulates expression of vascular endothelial growth factor in feto-placental endothelium from normal and late-onset pre-eclamptic pregnancies
Jesenia Acurio et al.
PURINERGIC SIGNALLING (2017)
The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets
Bertrand Allard et al.
IMMUNOLOGICAL REVIEWS (2017)
Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
Paul A. Beavis et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
cAMP: a multifaceted modulator of immune synapse assembly and T cell activation
Vijay Bharathi Arumugham et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2017)
Adenosine contribution to normal renal physiology and chronic kidney disease
Carlos Oyarzun et al.
MOLECULAR ASPECTS OF MEDICINE (2017)
Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma
Si-Rui Ma et al.
MOLECULAR CANCER (2017)
CBirTox is a selective antigen-specific agonist of the Treg-IgA-microbiota homeostatic pathway
Katie L. Alexander et al.
PLOS ONE (2017)
Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure
Eunyoung Tak et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)
Cancer associated fibroblasts: An essential role in the tumor microenvironment
Leilei Tao et al.
ONCOLOGY LETTERS (2017)
The adenosine A2b receptor promotes tumor progression of bladder urothelial carcinoma by enhancing MAPK signaling pathway
Yihong Zhou et al.
ONCOTARGET (2017)
Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer
Yusuke Inoue et al.
ONCOTARGET (2017)
Inhibition of A2A Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455
Stefania Gessi et al.
FRONTIERS IN PHARMACOLOGY (2017)
Engineering Chimeric Antigen Recptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel
Melita Irving et al.
FRONTIERS IN IMMUNOLOGY (2017)
A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment
Melanie Mediavilla-Varela et al.
NEOPLASIA (2017)
CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF--mTOR-HIF-1 signaling in patients with non-small cell lung cancer
Jieyao Li et al.
ONCOIMMUNOLOGY (2017)
Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer
Saly Al-Taei et al.
ONCOIMMUNOLOGY (2017)
Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation
Xiaohu Wang et al.
EBIOMEDICINE (2017)
Targeting immunosuppressive adenosine in cancer
D. Vijayan et al.
NATURE REVIEWS CANCER (2017)
Mechanisms regulating T-cell infiltration and activity in solid tumors
E. Lanitis et al.
ANNALS OF ONCOLOGY (2017)
The Adenosine A1 Receptor Antagonist DPCPX Inhibits Tumor Progression via the ERK/JNK Pathway in Renal Cell Carcinoma
Yihong Zhou et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)
CD73 Promotes Resistance to HER2/ErbB2 Antibody Therapy
Martin Turcotte et al.
CANCER RESEARCH (2017)
Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes
Josephine Salimu et al.
JOURNAL OF EXTRACELLULAR VESICLES (2017)
Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis
Yiming Xu et al.
EMBO MOLECULAR MEDICINE (2017)
Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis
Arabella Young et al.
CANCER RESEARCH (2017)
MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Julia Reinhardt et al.
CANCER RESEARCH (2017)
Suppression of Lymphocyte Functions by Plasma Exosomes Correlates with Disease Activity in Patients with Head and Neck Cancer
Sonja Ludwig et al.
CLINICAL CANCER RESEARCH (2017)
HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer
Tristan A. Barnes et al.
BRITISH JOURNAL OF CANCER (2017)
A novel CD73-blocking antibody reduces production of immunosuppressive adenosine and restores T cell function
Emily C. Piccione et al.
CANCER RESEARCH (2017)
Targeting the adenosine immunosuppressive pathway for cancer immunotherapy with small molecule agents
Pierre Fons et al.
CANCER RESEARCH (2017)
Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects
Shuji Kojima et al.
DOSE-RESPONSE (2017)
Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis
Begum Erdogan et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2017)
Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies
Kristin G. Anderson et al.
CANCER CELL (2017)
The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?
Zishuo I. Hu et al.
CURRENT BREAST CANCER REPORTS (2017)
The Principles of Engineering Immune Cells to Treat Cancer
Wendell A. Lim et al.
CELL (2017)
A Systems Oncology Approach Identifies NT5E as a Key Metabolic Regulator in Tumor Cells and Modulator of Platinum Sensitivity
Ekaterina Nevedomskaya et al.
JOURNAL OF PROTEOME RESEARCH (2016)
Human ectonucleotidase-expressing CD25high Th17 cells accumulate in breast cancer tumors and exert immunosuppressive functions
Marion Thibaudin et al.
ONCOIMMUNOLOGY (2016)
Myeloid cells in the tumor microenvironment: Role of adenosine
Silvana Morello et al.
ONCOIMMUNOLOGY (2016)
Diverse Mechanisms of Sp1-Dependent Transcriptional Regulation Potentially Involved in the Adaptive Response of Cancer Cells to Oxygen-Deficient Conditions
Shiro Koizume et al.
CANCERS (2016)
Adenosine A2A receptor promotes collagen type III synthesis via -catenin activation in human dermal fibroblasts
Gibran Shaikh et al.
BRITISH JOURNAL OF PHARMACOLOGY (2016)
Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses
Arabella Young et al.
CANCER CELL (2016)
Extracellular Adenosine Production by ecto-5′-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis
Florian Wirsdoerfer et al.
CANCER RESEARCH (2016)
A therapeutic antibody that inhibits CD73 activity by dual mechanisms
Bryan C. Barnhart et al.
CANCER RESEARCH (2016)
Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis
Deepak Mittal et al.
CANCER RESEARCH (2016)
Immunosuppressive activities of adenosine in cancer
Bertrand Allard et al.
CURRENT OPINION IN PHARMACOLOGY (2016)
Monoclonal antibodies targeting CD38 in hematological malignancies and beyond
Niels W. C. J. van de Donk et al.
IMMUNOLOGICAL REVIEWS (2016)
Mesenchymal stromal cells derived from cervical cancer produce high amounts of adenosine to suppress cytotoxic T lymphocyte functions
Maria de Lourdes Mora-Garcia et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2016)
Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action
James C. Geoghegan et al.
MABS (2016)
Overexpression of CD39 in hepatocellular carcinoma is an independent indicator of poor outcome after radical resection
Xiao-Yan Cai et al.
MEDICINE (2016)
The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review)
Kuo Yan et al.
MOLECULAR MEDICINE REPORTS (2016)
Mechanisms and regulation of endothelial VEGF receptor signalling
Michael Simons et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Adenosine arrests breast cancer cell motility by A3 receptor stimulation
Carola Ledderose et al.
Purinergic Signalling (2016)
Adenosinergic Immunosuppression by Human Mesenchymal Stromal Cells Requires Co-Operation with T cells
Erja Kerkela et al.
STEM CELLS (2016)
Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies
Mohamed R. Akl et al.
ONCOTARGET (2016)
Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression
Claudia Sorrentino et al.
ONCOTARGET (2016)
Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals
Fengqin Fang et al.
CELL REPORTS (2016)
Augmentation of CAR T-cell Trafficking and Antitumor Efficacy by Blocking Protein Kinase A Localization
Kheng Newick et al.
CANCER IMMUNOLOGY RESEARCH (2016)
Molecular Mechanisms for cAMP-Mediated immunoregulationin T cells - Role of Anchored Protein Kinase A Signaling Units
Vanessa L. Wehbi et al.
FRONTIERS IN IMMUNOLOGY (2016)
The ecto-ATPDase CD39 is involved in the acquisition of the immunoregulatory phenotype by M-CSF-macrophages and ovarian cancer tumor-associated macrophages: Regulatory role of IL-27
Senan M. d'Almeida et al.
ONCOIMMUNOLOGY (2016)
Targeting CD73 in the tumor microenvironment with MEDI9447
Carl M. Hay et al.
ONCOIMMUNOLOGY (2016)
Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages - a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape
Itsaso Montalban del Barrio et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2016)
Adenosine A1 receptor modifies P53 expression and apoptosis in breast cancer cell line Mcf-7
Nikbakht M. Dastjerdi et al.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY (2016)
Purinergic regulation of the immune system
Caglar Cekic et al.
NATURE REVIEWS IMMUNOLOGY (2016)
Adenosine A2b receptor promotes progression of human oral cancer
Hiroki Kasama et al.
BMC CANCER (2015)
CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression
Maria Rosa Bono et al.
FEBS LETTERS (2015)
Acquisition of new tumor cell properties by MSC-derived exosomes
Yuanyuan Yang et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2015)
Multi-Inhibitory Effects of A2A Adenosine Receptor Signaling on Neutrophil Adhesion Under Flow
Tadayuki Yago et al.
JOURNAL OF IMMUNOLOGY (2015)
Bordetella pertussis Adenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 Phosphatase
Ondrej Cerny et al.
JOURNAL OF IMMUNOLOGY (2015)
SLEEP DEPRIVATION AND HIPPOCAMPAL VULNERABILITY: CHANGES IN NEURONAL PLASTICITY, NEUROGENESIS AND COGNITIVE FUNCTION
J. C. Kreutzmann et al.
NEUROSCIENCE (2015)
p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death
J. S. Long et al.
ONCOGENE (2015)
Immunological mechanisms of the antitumor effects of supplemental oxygenation
Stephen M. Hatfield et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
The future of EPAC-targeted therapies: agonism versus antagonism
Euan Parnell et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation
Jeniffer B. Hernandez et al.
NATURE COMMUNICATIONS (2015)
Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model
Claudia Sorrentino et al.
ONCOTARGET (2015)
The cAMP response element modulator (CREM) regulates TH2 mediated inflammation
Eva Verjans et al.
ONCOTARGET (2015)
Prognostic Significance of Serum Alkaline Phosphatase Level in Osteosarcoma: A Meta-Analysis of Published Data
Hai-Yong Ren et al.
BIOMED RESEARCH INTERNATIONAL (2015)
Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses
Paul A. Beavis et al.
CANCER IMMUNOLOGY RESEARCH (2015)
Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells
Patricia S. de Araujo-Souza et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2015)
Adenosine regulates radiation therapy-induced anti-tumor immunity
Erik Wennerberg et al.
Journal for ImmunoTherapy of Cancer (2015)
Unraveling the contribution of ectoenzymes to myeloma life and survival in the bone marrow niche
Valeria Quarona et al.
MARROW (2015)
Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis
J. Z. Zhou et al.
ONCOGENE (2015)
Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
Jeremy Bastid et al.
CANCER IMMUNOLOGY RESEARCH (2015)
FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas
Pichai Raman et al.
CANCER INFORMATICS (2015)
Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment
Caglar Cekic et al.
CANCER RESEARCH (2014)
Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment
Caglar Cekic et al.
CANCER RESEARCH (2014)
Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor
Deepak Mittal et al.
CANCER RESEARCH (2014)
Human CD4+CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells
P. J. Schuler et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2014)
Transcriptional regulation by hypoxia inducible factors
Veronica L. Dengler et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)
TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence
Jian Ye et al.
EMBO MOLECULAR MEDICINE (2014)
Anti-CD73 therapy impairs tumor angiogenesis
Bertrand Allard et al.
INTERNATIONAL JOURNAL OF CANCER (2014)
Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review)
David Hoskin et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2014)
Adenosine Physiology, Pharmacology, and Clinical Applications
Jamie Layland et al.
JACC-CARDIOVASCULAR INTERVENTIONS (2014)
IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients
Geok Choo Sim et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Role of TGF-β Signaling in Generation of CD39+CD73+ Myeloid Cells in Tumors
Sergey V. Ryzhov et al.
JOURNAL OF IMMUNOLOGY (2014)
Adenosine A2A Receptor as a Drug Discovery Target
Manuel de Lera Ruiz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection
Stephen M. Hatfield et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2014)
PKA Reduces the Rat and Human KCa3.1 Current, CaM Binding, and Ca2+ Signaling, Which Requires Ser332/334 in the CaM-Binding C Terminus
Raymond Wong et al.
JOURNAL OF NEUROSCIENCE (2014)
Two Histone/Protein Acetyltransferases, CBP and p300, Are Indispensable for Foxp3+ T-Regulatory Cell Development and Function
Yujie Liu et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors
Elisabet Aliagas et al.
MEDIATORS OF INFLAMMATION (2014)
Characterization of Human CD39+ Th17 Cells with Suppressor Activity and Modulation in Inflammatory Bowel Disease
Maria Serena Longhi et al.
PLOS ONE (2014)
ATP-Based Chemotherapy Response Assay in Primary or Recurrent Ovarian and Peritoneal Cancer
Maria Lee et al.
YONSEI MEDICAL JOURNAL (2014)
The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study
Geoff Bellingan et al.
LANCET RESPIRATORY MEDICINE (2014)
Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death
Encouse B. Golden et al.
ONCOIMMUNOLOGY (2014)
Extracellular Generation of Adenosine by the Ectonucleotidases CD39 and CD73 Promotes Dermal Fibrosis
Patricia Fernandez et al.
AMERICAN JOURNAL OF PATHOLOGY (2013)
Differential effect of adenosine receptors on growth of human colon cancer HCT 116 and HT-29 cell lines
Monika Sakowicz-Burkiewicz et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2013)
Hypoxia and P1 receptor activation regulate the high-affinity concentrative adenosine transporter CNT2 in differentiated neuronal PC12 cells
Lorena Medina-Pulido et al.
BIOCHEMICAL JOURNAL (2013)
Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac
Amanda G. Vang et al.
BIOCHEMICAL JOURNAL (2013)
Emerging Roles of Human Prostatic Acid Phosphatase
Hoon Young Kong et al.
BIOMOLECULES & THERAPEUTICS (2013)
Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth
Melanie Mediavilla-Varela et al.
CANCER BIOLOGY & THERAPY (2013)
Tumor promotion through the mesenchymal stem cell compartment in human hepatocellular carcinoma
Pratika Y. Hernanda et al.
CARCINOGENESIS (2013)
Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs
Bertrand Allard et al.
CLINICAL CANCER RESEARCH (2013)
A review on CXCR4/CXCL12 axis in oncology: No place to hide
Urszula M. Domanska et al.
EUROPEAN JOURNAL OF CANCER (2013)
CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+ T cells contributes to their regulatory function
Lesley Ann Smyth et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2013)
Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T-cell priming capacity
John Challier et al.
IMMUNOLOGY (2013)
The Adenosine-Dependent Angiogenic Switch of Macrophages to an M2-Like Phenotype is Independent of Interleukin-4 Receptor Alpha (IL-4Rα) Signaling
Christopher James Ferrante et al.
INFLAMMATION (2013)
Forskolin-inducible cAMP Pathway Negatively Regulates T-cell Proliferation by Uncoupling the Interleukin-2 Receptor Complex
Georgialina Rodriguez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Extracellular adenosine regulates naive T cell development and peripheral maintenance
Caglar Cekic et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
Cholera Toxin Directly Enhances IL-17A Production from Human CD4+ T Cells
Hsing-Chuan Tsai et al.
JOURNAL OF IMMUNOLOGY (2013)
Selective Inhibition of KCa3.1 Channels Mediates Adenosine Regulation of the Motility of Human T Cells
Ameet A. Chimote et al.
JOURNAL OF IMMUNOLOGY (2013)
Anti-Human CD73 Monoclonal Antibody Inhibits Metastasis Formation in Human Breast Cancer by Inducing Clustering and Internalization of CD73 Expressed on the Surface of Cancer Cells
Mikkel G. Terp et al.
JOURNAL OF IMMUNOLOGY (2013)
Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease
Jens M. Poth et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2013)
Interrogating cAMP-dependent Kinase Signaling in Jurkat T Cells via a Protein Kinase A Targeted Immune-precipitation Phosphoproteomics Approach
Piero Giansanti et al.
MOLECULAR & CELLULAR PROTEOMICS (2013)
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39
Ivan D. Mascanfroni et al.
NATURE IMMUNOLOGY (2013)
Circulating and Tumor-Infiltrating Myeloid-Derived Suppressor Cells in Patients with Colorectal Carcinoma
Bin Zhang et al.
PLOS ONE (2013)
Ensemble of Gene Signatures Identifies Novel Biomarkers in Colorectal Cancer Activated through PPAR gamma and TNF alpha Signaling
Stefano Maria Pagnotta et al.
PLOS ONE (2013)
CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer
Sherene Loi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors
Paul A. Beavis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis
Christophe J. Desmet et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
A2B adenosine receptor blockade inhibits growth of prostate cancer cells
Qiang Wei et al.
PURINERGIC SIGNALLING (2013)
Detecting adenosine triphosphate in the pericellular space
Simonetta Falzoni et al.
INTERFACE FOCUS (2013)
Advanced stage of breast cancer hoist alkaline phosphatase activity: risk factor for females in India
A. K. Singh et al.
3 BIOTECH (2013)
Blockade of A2b Adenosine Receptor Reduces Tumor Growth and Immune Suppression Mediated by Myeloid-Derived Suppressor Cells in a Mouse Model of Melanoma
Raffaella Iannone et al.
NEOPLASIA (2013)
The adenosinergic system in cancer Key therapeutic target
Rosalinda Sorrentino et al.
ONCOIMMUNOLOGY (2013)
A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes
Alberto L. Horenstein et al.
ONCOIMMUNOLOGY (2013)
Modulation of KV1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex
Zerrin Kuras et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2012)
Regulation of Macrophage Function by Adenosine
Gyorgy Hasko et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)
Regulation of Neutrophil Function by Adenosine
Kathryn E. Barletta et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)
Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor
Adam T. Waickman et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2012)
CD73-Deficient Mice Are Resistant to Carcinogenesis
John Stagg et al.
CANCER RESEARCH (2012)
Adenosine Induces Apoptosis in SBC-3 Human Lung Cancer Cells through A3 Adenosine Receptor-Dependent AMID Upregulation
Takeshi Kanno et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2012)
A3 Adenosine Receptor-Mediated p53-Dependent Apoptosis in Lu-65 Human Lung Cancer Cells
Tai-ichiro Otsuki et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2012)
Distinctive immunoregulatory effects of adenosine on T cells of older humans
Charles S. Hesdorffer et al.
FASEB JOURNAL (2012)
Adenosine promotes alternative macrophage activation via A2A and A2B receptors
Balazs Csoka et al.
FASEB JOURNAL (2012)
Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression
Fanny Chalmin et al.
IMMUNITY (2012)
cAMP-responsive Element Modulator α (CREMα) Suppresses IL-17F Protein Expression in T Lymphocytes from Patients with Systemic Lupus Erythematosus (SLE)
Christian M. Hedrich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
CD73-Generated Adenosine: Orchestrating the Tumor-Stroma Interplay to Promote Cancer Growth
Bertrand Allard et al.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2012)
Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury
Li Li et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors
Caglar Cekic et al.
JOURNAL OF IMMUNOLOGY (2012)
Inhibition of CD73 Improves B Cell-Mediated Anti-Tumor Immunity in a Mouse Model of Melanoma
Giovanni Forte et al.
JOURNAL OF IMMUNOLOGY (2012)
CD38 deficiency in the tumor microenvironment attenuates glioma progression and modulates features of tumor-associated microglia/macrophages
Ayelet Levy et al.
NEURO-ONCOLOGY (2012)
Extracellular NAD+: a danger signal hindering regulatory T cells
Sahil Adriouch et al.
MICROBES AND INFECTION (2012)
Multiple Analyses of G-Protein Coupled Receptor (GPCR) Expression in the Development of Gefitinib-Resistance in Transforming Non-Small-Cell Lung Cancer
Naoko Kuzumaki et al.
PLOS ONE (2012)
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
Kakali Sarkar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Cellular function and molecular structure of ecto-nucleotidases
Herbert Zimmermann et al.
PURINERGIC SIGNALLING (2012)
The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway
Akio Ohta et al.
FRONTIERS IN IMMUNOLOGY (2012)
A3 Receptors Are Overexpressed in Pleura from Patients with Mesothelioma and Reduce Cell Growth via Akt/Nuclear Factor-κB Pathway
Katia Varani et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)
Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity
Sebastian F. M. Haeusler et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2011)
CNT1 Expression Influences Proliferation and Chemosensitivity in Drug-Resistant Pancreatic Cancer Cells
Yangzom D. Bhutia et al.
CANCER RESEARCH (2011)
CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis
John Stagg et al.
CANCER RESEARCH (2011)
Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-β
Frederico S. Regateiro et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2011)
Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
Gennady G. Yegutkin et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2011)
cAMP-responsive Element Modulator (CREM)α Protein Signaling Mediates Epigenetic Remodeling of the Human Interleukin-2 Gene IMPLICATIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS
Christian M. Hedrich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
cAMP-responsive Element Modulator (CREM)α Protein Induces Interleukin 17A Expression and Mediates Epigenetic Alterations at the Interleukin-17A Gene Locus in Patients with Systemic Lupus Erythematosus
Thomas Rauen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Molecular mechanisms of A3 adenosine receptor-induced G1 cell cycle arrest and apoptosis in androgen-dependent and independent prostate cancer cell lines: involvement of intrinsic pathway
Mahmoud Aghaei et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2011)
CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice
Long Wang et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production
Aled Clayton et al.
JOURNAL OF IMMUNOLOGY (2011)
The A2B Adenosine Receptor Promotes Th17 Differentiation via Stimulation of Dendritic Cell IL-6
Jeffrey M. Wilson et al.
JOURNAL OF IMMUNOLOGY (2011)
Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells
Sergey Ryzhov et al.
JOURNAL OF IMMUNOLOGY (2011)
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
Judith Y. Altarejos et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors-An Update
Bertil B. Fredholm et al.
PHARMACOLOGICAL REVIEWS (2011)
Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
Mickael Michaud et al.
SCIENCE (2011)
Pain-relieving prospects for adenosine receptors and ectonucleotidases
Mark J. Zylka
TRENDS IN MOLECULAR MEDICINE (2011)
CD39/Adenosine Pathway Is Involved in AIDS Progression
Maria Nikolova et al.
PLOS PATHOGENS (2011)
Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors
Stefania Gessi et al.
BIOCHEMICAL PHARMACOLOGY (2010)
High-resolution mapping of prostaglandin E2-dependent signaling networks identifies a constitutively active PKA signaling node in CD8+CD45RO+ T cells
Nikolaus G. Oberprieler et al.
BLOOD (2010)
Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A1 adenosine receptors
Masaru Saito et al.
CANCER LETTERS (2010)
CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression
Dachuan Jin et al.
CANCER RESEARCH (2010)
Wnt/β-Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy
Luca Gattinoni et al.
CLINICAL CANCER RESEARCH (2010)
Effects of cyclic AMP on expression of LFA-1, Mac-1, and VLA-4 and eosinophilic differentiation of a human leukemia cell line, EoL-1
Eun-Young Jung et al.
EUROPEAN JOURNAL OF HAEMATOLOGY (2010)
Adenosine mediated desensitization of cAMP signaling enhances T-cell responses
Ailian Yang et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2010)
Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death
Leonora Himer et al.
FASEB JOURNAL (2010)
CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice
Xiaofeng Sun et al.
GASTROENTEROLOGY (2010)
HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia
Meixiang Yang et al.
IMMUNOLOGY AND CELL BIOLOGY (2010)
A Key Role for the Phosphorylation of Ser440 by the Cyclic AMP-dependent Protein Kinase in Regulating the Activity of the Src Homology 2 Domain-containing Inositol 5′-Phosphatase (SHIP1)
Jun Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Involvement of SLC17A9-dependent Vesicular Exocytosis in the Mechanism of ATP Release during T Cell Activation
Akihiro Tokunaga et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
cAMP/CREB-mediated Transcriptional Regulation of Ectonucleoside Triphosphate Diphosphohydrolase 1 (CD39) Expression
Hui Liao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Distinct Roles of Adenylyl Cyclase VII in Regulating the Immune Responses in Mice
Biyan Duan et al.
JOURNAL OF IMMUNOLOGY (2010)
The Role of the Transcription Factor CREB in Immune Function
Andy Y. Wen et al.
JOURNAL OF IMMUNOLOGY (2010)
CD73 represses pro-inflammatory responses in human endothelial cells
Jana K. G. Gruenewald et al.
JOURNAL OF INFLAMMATION-LONDON (2010)
Modulation of Cytokine Production by Cyclic Adenosine Monophosphate Analogs in Human Leukocytes
Sarah Gerlo et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2010)
Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins
Guillaume Pidoux et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2010)
Vasoactive Intestinal Peptide Induces Cell Cycle Arrest and Regulatory Functions in Human T Cells at Multiple Levels
Per Anderson et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4(+) T cells
Alexandr V. Bazhin et al.
MOLECULAR IMMUNOLOGY (2010)
BioNumbers-the database of key numbers in molecular and cell biology
Ron Milo et al.
NUCLEIC ACIDS RESEARCH (2010)
Adenosine A1 receptor, a target and regulator of estrogen receptor-α action, mediates the proliferative effects of estradiol in breast cancer
Z. Lin et al.
ONCOGENE (2010)
Extracellular adenosine triphosphate and adenosine in cancer
J. Stagg et al.
ONCOGENE (2010)
PDE8 Regulates Rapid Teff Cell Adhesion and Proliferation Independent of ICER
Amanda G. Vang et al.
PLOS ONE (2010)
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
John Stagg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Differential ectonucleotidase expression in human bladder cancer cell lines
Joseli Stella et al.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2010)
Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
Holger K. Eltzschig et al.
BLOOD (2009)
Chemotherapy induces ATP release from tumor cells
Isabelle Martins et al.
CELL CYCLE (2009)
Hypoxia-inducible Factor-Dependent Repression of Equilibrative Nucleoside Transporter 2 Attenuates Mucosal Inflammation During Intestinal Hypoxia
Julio C. Morote-Garcia et al.
GASTROENTEROLOGY (2009)
The functional network of ion channels in T lymphocytes
Michael D. Cahalan et al.
IMMUNOLOGICAL REVIEWS (2009)
Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling
Carsten Linnemann et al.
IMMUNOLOGY (2009)
Mechanisms of Induction of Adenosine Receptor Genes and Its Functional Significance
Cynthia St. Hilaire et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A(2a) adenosine receptors
Yoshiyuki Yasuda et al.
JOURNAL OF GASTROENTEROLOGY (2009)
Human Follicular Lymphoma CD39+-Infiltrating T Cells Contribute to Adenosine-Mediated T Cell Hyporesponsiveness
Shannon P. Hilchey et al.
JOURNAL OF IMMUNOLOGY (2009)
Inhibition of cAMP Degradation Improves Regulatory T Cell-Mediated Suppression
Tobias Bopp et al.
JOURNAL OF IMMUNOLOGY (2009)
The A2B Adenosine Receptor Impairs the Maturation and Immunogenicity of Dendritic Cells
Jeffrey M. Wilson et al.
JOURNAL OF IMMUNOLOGY (2009)
A2A Adenosine Receptor May Allow Expansion of T Cells Lacking Effector Functions in Extracellular Adenosine-Rich Microenvironments
Akio Ohta et al.
JOURNAL OF IMMUNOLOGY (2009)
Adenylyl Cyclase-A-kinase Anchoring Protein Complexes: The Next Dimension in cAMP Signaling
Carmen W. Dessauer
MOLECULAR PHARMACOLOGY (2009)
A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence
M. S. Alam et al.
MUCOSAL IMMUNOLOGY (2009)
Heightened NTPDase-1/CD39 expression and angiogenesis in radiation proctitis
Sunil Sheth et al.
PURINERGIC SIGNALLING (2009)
Prostatic acid phosphatase, a neglected ectonucleotidase
Herbert Zimmermann
PURINERGIC SIGNALLING (2009)
A2B and A3 Adenosine Receptors Modulate Vascular Endothelial Growth Factor and Interleukin-8 Expression in Human Melanoma Cells Treated with Etoposide and Doxorubicin
Stefania Merighi et al.
NEOPLASIA (2009)
Adenosine A3 Receptor Suppresses Prostate Cancer Metastasis by Inhibiting NADPH Oxidase Activity
Sarvesh Jajoo et al.
NEOPLASIA (2009)
Epac and PKA: a tale of two intracellular cAMP receptors
Xiaodong Cheng et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2008)
Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade
Gennady G. Yegutkin
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)
Adenosine receptors in regulation of dendritic cell differentiation and function
Sergey V. Novitskiy et al.
BLOOD (2008)
Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression
Yunyun Su et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2008)
Modulation of murine dendritic cell function by adenine nucleotides and adenosine:: Involvement of the A2B receptor
Abduelhakem Ben Addi et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2008)
Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function
Balazs Csoka et al.
FASEB JOURNAL (2008)
Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis
Silvia Rossi Paccani et al.
INFECTION AND IMMUNITY (2008)
CREB, ATF, and AP-1 transcription factors regulate IFN-γ secretion by human T cells in response to mycobacterial antigen
Buka Samten et al.
JOURNAL OF IMMUNOLOGY (2008)
Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels
Ursula Schenk et al.
SCIENCE SIGNALING (2008)
Host A2B adenosine receptors promote carcinoma growth
Sergey Ryzhov et al.
NEOPLASIA (2008)
A2B adenosine receptor dampens hypoxia-induced vascular leak
Tobias Eckle et al.
BLOOD (2008)
A(2A) receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells
Paul E. Zarek et al.
BLOOD (2008)
Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway
Sansana Sawasdikosol et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
RNA interference of ecto-5′-nucleotidase (CD73) inhibits human breast cancer cell growth and invasion
Xiuling Zhi et al.
CLINICAL & EXPERIMENTAL METASTASIS (2007)
Disordered purinergic signaling inhibits pathological angiogenesis in Cd39/Entpd1-null mice
Shaun W. Jackson et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
A2A adenosine receptors and C/EBPβ are crucially required for IL-10 production by macrophages exposed to Escherichia coli
Balazs Csoka et al.
BLOOD (2007)
Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1α, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells
Stefania Merighi et al.
MOLECULAR PHARMACOLOGY (2007)
Adenosine Deamination sustains dendritic cell activation in inflammation
Melanie D. Desrosiers et al.
JOURNAL OF IMMUNOLOGY (2007)
CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression:: a role for DNA methylation
Hyoung-Pyo Kim et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of Bad in glioblastoma cells
Stefania Merighi et al.
MOLECULAR PHARMACOLOGY (2007)
Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase a type I signaling
Tatiana Raskovalova et al.
CANCER RESEARCH (2007)
Cyclic adenosine monophosphate is a key component of regulatory T cell mediated suppression
Tobias Bopp et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Adenosine receptors in colon carcinoma tissues and colon tumoral cell lines:: Focus on the A3 adenosine subtype
Stefania Gessi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2007)
Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages
Arvand Haschemi et al.
JOURNAL OF IMMUNOLOGY (2007)
Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56δ subunit
Jung-Hyuck Ahn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Functional dissection identifies a conserved noncoding sequence-1 core that mediates IL13 and IL4 transcriptional enhancement
Jannine M. Strempel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A(2A) receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter
Madhuri Ramanathan et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Extracellular NAD and ATP: Partners in immune cell modulation
Friedrich Haag et al.
PURINERGIC SIGNALLING (2007)
A2A adenosine receptor protects tumors from antitumor T cells
Akio Ohta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Adenosine-mediated inhibition of the cytotoxic activity and cytokine production by activated natural killer cells
Anna Lokshin et al.
CANCER RESEARCH (2006)
Diabetes-induced decrease of adenosine kinase expression impairs the proliferation potential of diabetic rat T lymphocytes
Monika Sakowicz-Burkiewicz et al.
IMMUNOLOGY (2006)
A1 adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosine-induced RCR-1 astrocytoma cell death
Katsunari Sai et al.
NEUROTOXICOLOGY (2006)
Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells
Stefania Merighi et al.
BIOCHEMICAL PHARMACOLOGY (2006)
Adenosine produced via the CD73/ecto-5'-nucleotidase pathway has no impact on erythropoietin production but is associated with reduced kidney weight
Burcin Oezueyaman et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2006)
Ecto-5′-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury
Jonathan B. Volmer et al.
JOURNAL OF IMMUNOLOGY (2006)
Extracellular Nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells - Involvement of P2 receptors and adenosine transporters
CG da Silva et al.
CIRCULATION RESEARCH (2006)
The antitumor effect of LJ-529, a novel agonist to A3 adenosine receptor, in both estrogen receptor-positive and estrogen receptor-negative human breast cancers
H Chung et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Multiple cAMP-induced signaling cascades regulate prolactin expression in T cells
S Gerlo et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2006)
Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism
ZH Németh et al.
JOURNAL OF IMMUNOLOGY (2005)
Adenosine prevents neutrophil adhesion to human endothelial cells after hypoxia/reoxygenation
JG Kilian et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2005)
HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia
HK Eltzschig et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
RNA interference targeting of A1 receptor-overexpressing breast carcinoma cells leads to diminished rates of cell proliferation and induction of apoptosis
A Mirza et al.
CANCER BIOLOGY & THERAPY (2005)
Immunomodulatory impact of the A2A adenosine receptor on the profile of chemokines produced by neutrophils
SR McColl et al.
FASEB JOURNAL (2005)
GS protein-coupled adenosine receptor signaling and lytic function of activated NK cells
T Raskovalova et al.
JOURNAL OF IMMUNOLOGY (2005)
A3 adenosine receptors modulate hypoxia-inducible factor-1α expression in human A375 melanoma cells
S Merighi et al.
NEOPLASIA (2005)
Phosphorylation of β-catenin by cyclic AMP-dependent protein kinase stabilizes β-catenin through inhibition of its ubiquitination
S Hino et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins
M Barzik et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A3 adenosine receptor activation inhibits cell proliferation via phosphatidylinositol 3-kinase/Akt-dependent inhibition of the extracellular signal-regulated kinase 1/2 phosphorylation in A375 human melanoma cells
S Merighi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Egr-2 and Egr-3 are negative regulators of T cell activation
M Safford et al.
NATURE IMMUNOLOGY (2005)
Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1
A Desai et al.
MOLECULAR PHARMACOLOGY (2005)
G-protein signaling: back to the future
CR McCudden et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells
CG Radu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules
A Johnston et al.
CLINICAL IMMUNOLOGY (2005)
A2A adenosine receptor induction inhibits IFN-γ production in murine CD4+ T cells
CM Lappas et al.
JOURNAL OF IMMUNOLOGY (2005)
Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors
S Minguet et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2005)
Expression of A3 adenosine receptors in human lymphocytes:: Up-regulation in T cell activation
S Gessi et al.
MOLECULAR PHARMACOLOGY (2004)
Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion
TG Bivona et al.
JOURNAL OF CELL BIOLOGY (2004)
IFN-α induced adenosine production on the endothelium:: A mechanism mediated by CD73 (ecto-5′-nucleotidase) up-regulation
J Niemelä et al.
JOURNAL OF IMMUNOLOGY (2004)
Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors
X Farré et al.
INTERNATIONAL JOURNAL OF CANCER (2004)
Adenosine acts through A2 receptors to inhibit IL-2-induced tyrosine phosphorylation of STAT5 in T lymphocytes:: Role of cyclic adenosine 3',5'-monophosphate and phosphatases
H Zhang et al.
JOURNAL OF IMMUNOLOGY (2004)
Activation of A(2A) adenosine receptors inhibits expression of alpha 4/beta 1 integrin (very late antigen-4) on stimulated human neutrophils
GW Sullivan et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2004)
Wnt and β-catenin signaling target the expression of ecto-5′-nucleotidase and increase extracellular adenosine generation
J Spychala et al.
EXPERIMENTAL CELL RESEARCH (2004)
Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase
M Saitoh et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Adenosine induces dephosphorylation of myosin II regulatory light chain in cultured bovine corneal endothelial cells
SP Srinivas et al.
EXPERIMENTAL EYE RESEARCH (2004)
Inhibition of primary colon carcinoma growth and liver metastasis by the A3 adenosine receptor agonist CF101
G Ohana et al.
BRITISH JOURNAL OF CANCER (2003)
Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells
ND Khoa et al.
JOURNAL OF IMMUNOLOGY (2003)
Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras
N Dumaz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
An angiogenic switch in macrophages involving synergy between toll-like receptors 2, 4, 7, and 9 and adenosine A2A receptors
G Pinhal-Enfield et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
Adenosine slows migration of dendritic cells but does not affect other aspects of dendritic cell maturation
S Hofer et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2003)
Adherent leukocytes prevent adenosine formation and impair endothelial barrier function by ecto-5′-nucleotidase/CD73-dependent mechanism
T Henttinen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs
DE Lukashev et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Serine phosphorylation negatively regulates RhoA in vivo
SM Ellerbroek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells
E Panther et al.
BLOOD (2003)
cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression
T Grader-Beck et al.
BLOOD (2003)
Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3
CM Sheridan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Commitment of activated T cells to secondary responsiveness is enhanced by signals mediated by cAMP-dependent protein kinase A-I
M Vig et al.
MOLECULAR PHARMACOLOGY (2002)
Adenosine up-regulates cyclooxygenase-2 in human granulocytes:: Impact on the balance of eicosanoid generation
M Pouliot et al.
JOURNAL OF IMMUNOLOGY (2002)
Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells
S Merighi et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2002)
Inhibition of the NF-κB transcriptional activity by protein kinase A
N Takahashi et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)
Generation of CD4+CD45RA+ effector T cells by stimulation in the presence of cyclic adenosine 5′-monophosphate-elevating agents
A Suárez et al.
JOURNAL OF IMMUNOLOGY (2002)
Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase a type I
EM Aandahl et al.
JOURNAL OF IMMUNOLOGY (2002)
Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes
X Duhant et al.
JOURNAL OF IMMUNOLOGY (2002)
Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3-activated killer T cells
DW Hoskin et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
Adenosine suppresses α4β7 integrin-mediated adhesion of T lymphocytes to colon adenocarcinoma cells
WM MacKenzie et al.
EXPERIMENTAL CELL RESEARCH (2002)
Differential expression of adenosine receptors in human endothelial cells -: Role of A2B receptors in angiogenic factor regulation
I Feoktistov et al.
CIRCULATION RESEARCH (2002)
Role of vasodilator-stimulated phosphoprotein in protein kinase A-induced changes in endothelial junctional permeability
KM Comerford et al.
FASEB JOURNAL (2002)
Adenosine A2A and A2B receptor activation of erythropoietin production
JW Fisher et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2001)
Pharmacology of adenosine receptors in the vasculature
R Tabrizchi et al.
PHARMACOLOGY & THERAPEUTICS (2001)
Dynamics of cAMP-dependent protein kinase
DA Johnson et al.
CHEMICAL REVIEWS (2001)
Protein kinase C-θ participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the-180 site of the IL-2 promoter in normal human T lymphocytes
EE Solomou et al.
JOURNAL OF IMMUNOLOGY (2001)
Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activation
A Wakai et al.
SHOCK (2001)
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
T Vang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
Differential expression of human nucleoside transporters in normal and tumor tissue
M Pennycooke et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit expression of fas ligand in activated T lymphocytes by regulating c-myc, NF-κB, NF-AT, and early growth factors 2/3
M Delgado et al.
JOURNAL OF IMMUNOLOGY (2001)
CD28 and the tyrosine kinase Lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1
KD Carey et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Extracellular metabolism of ATP and other nucleotides
H Zimmermann
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2000)
Regulation of endothelial CD73 by adenosine: Paracrine pathway for enhanced endothelial barrier functions
S Narravula et al.
JOURNAL OF IMMUNOLOGY (2000)
Apparent involvement of the A2A subtype adenosine receptor in the anti-inflammatory interactions of CGS 21680, cyclopentyladenosine, and IB-MECA with human neutrophils
SS Visser et al.
BIOCHEMICAL PHARMACOLOGY (2000)
Adenosine inhibits IL-12 and TNF-α production via adenosine A2a receptor-dependent and independent mechanisms
G Haskó et al.
FASEB JOURNAL (2000)
cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating Ser-43 of Raf-1 in the MAPK/ERK pathway
C Ramstad et al.
CELLULAR SIGNALLING (2000)
Adenosine acts as an inhibitor of lymphoma cell growth: a major role for the A3 adenosine receptor
P Fishman et al.
EUROPEAN JOURNAL OF CANCER (2000)
Accelerated resequestration of cytosolic calcium and suppression of the pro-inflammatory activities of human neutrophils by CGS 21680 in vitro
R Anderson et al.
BRITISH JOURNAL OF PHARMACOLOGY (2000)
Integration of calcium and cyclic AMP signaling pathways by 14-3-3
CW Chow et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
分享论文
