期刊
FRONTIERS IN IMMUNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01140
关键词
monocyte; macrophage; autoimmune disease; count; function; polarization
类别
资金
- Qinghai Province Major R&D and Transformation Project [2018-NK-125]
- Xianyang Science and Technology Major Project [2017K01-34]
- Key Industrial Innovation Chains of Shaanxi Province [2018ZDCXL-NY-01-06]
- Youth Innovation Team of Shaanxi Universities
- PhD Research Startup Fund of Northwest Agriculture and Forestry University [00500/Z109021716]
Monocytes (Mo) and macrophages (M phi) are key components of the innate immune system and are involved in regulation of the initiation, development, and resolution of many inflammatory disorders. In addition, these cells also play important immunoregulatory and tissue-repairing roles to decrease immune reactions and promote tissue regeneration. Several lines of evidence have suggested a causal link between the presence or activation of these cells and the development of autoimmune diseases. In addition, Mo or M phi infiltration in diseased tissues is a hallmark of several autoimmune diseases. However, the detailed contributions of these cells, whether they actually initiate disease or perpetuate disease progression, and whether their phenotype and functional alteration are merely epiphenomena are still unclear in many autoimmune diseases. Additionally, little is known about their heterogeneous populations in different autoimmune diseases. Elucidating the relevance of Mo and M phi in autoimmune diseases and the associated mechanisms could lead to the identification of more effective therapeutic strategies in the future.
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