期刊
FRONTIERS IN IMMUNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.00852
关键词
atypical memory B cells; malaria; T-bet; B cell receptor signaling; TLR9; IFN-gamma
类别
资金
- Intramural Research Program of the National Institute of Health, National Institute of Allergy and Infectious Diseases
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000898] Funding Source: NIH RePORTER
Malaria is a deadly infectious disease associated with fundamental changes in the composition of the memory B cell (MBC) compartment, most notably a large expansion of T-bet(+) MBCs, termed atypical MBCs. However, we know little about the precursors of atypical MBCs and the conditions that drive their differentiation. We compared the responses of human tonsil naive B cells, MBCs, and germinal center B cells to a variety of stimulatory conditions. We determined that prolonged antigen presentation in the presence of CpG and IFN-gamma induced maximal expression of T-bet and other phenotypic markers of malaria-associated atypical MBCs primarily in naive B cells in vitro. Importantly T-bet(+) naive-derived B cells resembled atypical MBCs in their hypo-responsiveness to signaling through their B cell receptors. Thus, naive B cells can be induced to differentiate into phenotypically and functionally atypical-like MBCs in vitro under conditions that may prevail in chronic infectious diseases in vivo.
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