期刊
FRONTIERS IN IMMUNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.00799
关键词
macrophages; microRNA; endotoxin; Toll-like receptor; TAM
类别
资金
- European Community's Seventh Framework Program (FP7-2007-2013) [HEALTH-F4-2011-281608]
- Ministero dell'Istruzione dell'Universita e della Ricerca [2009JP9WTS_ 002, RBFR08CW8G]
- Italian Association for Cancer Research (AIRC-IG) [19213-2016]
The efficacy of macrophage-mediated inflammatory response relies on the coordinated expression of key factors, which expression is finely regulated at both transcriptional and post-transcriptional level. Several studies have provided compelling evidence that microRNAs play pivotal roles in modulating macrophage activation, polarization, tissue in filtration, and resolution of inflammation. In this review, we highlight the essential molecular mechanisms underlying the different phases of inflammation that are targeted by microRNAs to inhibit or accelerate restoration to tissue integrity and homeostasis. We further review the impact of microRNA-dependent regulation of tumor-associated macrophages and the relative implication for tumor biology.
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