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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Inflamed Lymphatic Endothelium Suppresses Dendritic Cell Maturation and Function via Mac-1/ICAM-1-Dependent Mechanism
Simona Podgrabinska et al.
JOURNAL OF IMMUNOLOGY (2009)
LFA-1 is critical for regulatory T cell homeostasis and function
Jillian Wohler et al.
MOLECULAR IMMUNOLOGY (2009)
Kindlin-3 is required for β2 integrin-mediated leukocyte adhesion to endothelial cells
Markus Moser et al.
NATURE MEDICINE (2009)
An integrin αvβ3-c-Src oncogenic unit promotes anchorage-independence and tumor progression
Jay S. Desgrosellier et al.
NATURE MEDICINE (2009)
Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis
Andrea T. Borchers et al.
SEMINARS IN IMMUNOPATHOLOGY (2009)
Mucins in cancer: function, prognosis and therapy
Donald W. Kufe
NATURE REVIEWS CANCER (2009)
Myeloid-derived suppressor cells as regulators of the immune system
Dmitry I. Gabrilovich et al.
NATURE REVIEWS IMMUNOLOGY (2009)
Soluble intercellular adhesion molecule-1 as a prognostic marker for stage II colorectal cancer patients
Yuji Toiyama et al.
ANNALS OF SURGICAL ONCOLOGY (2008)
CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks
Karen E. Anderson et al.
BLOOD (2008)
Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia
Valter Gattei et al.
BLOOD (2008)
CD49d expression is an independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a prognostic parameter with therapeutic potential
Tait D. Shanafelt et al.
BRITISH JOURNAL OF HAEMATOLOGY (2008)
Cell Motility in Chronic Lymphocytic Leukemia: Defective Rap1 and αLβ2 Activation by Chemokine
Kathleen J. Till et al.
CANCER RESEARCH (2008)
Loss of E-cadherin promotes ovarian cancer metastasis via alpha(5)-integrin, which is a therapeutic target
Kenjiro Sawada et al.
CANCER RESEARCH (2008)
The mammary progenitor marker CD61/β3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis
Francois Vaillant et al.
CANCER RESEARCH (2008)
Regulatory T cells and immune tolerance
Shimon Sakaguchi et al.
CELL (2008)
Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds α5β1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study
Alejandro D. Ricart et al.
CLINICAL CANCER RESEARCH (2008)
CD49d expression is an independent risk factor of progressive disease in early stage chronic lymphocytic leukemia
Davide Rossi et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2008)
Integrin-dependent phagocytosis - spreading from microadhesion to new concepts
Aurelien G. Dupuy et al.
JOURNAL OF CELL SCIENCE (2008)
TGF-β-dependent suppressive function of Tregs requires wild-type bevels of CD18 in a mouse model of psoriasis
Honglin Wang et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric brain tumor consortium study PBTC-012
Tobey J. MacDonald et al.
JOURNAL OF CLINICAL ONCOLOGY (2008)
A multicenter phase II study of volociximab in patients with relapsed metastatic melanoma
J. Barton
JOURNAL OF CLINICAL ONCOLOGY (2008)
Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme
David A. Reardon et al.
JOURNAL OF CLINICAL ONCOLOGY (2008)
Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells
Rachael A. Clark et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Kindlin-3 is essential for integrin activation and platelet aggregation
Markus Moser et al.
NATURE MEDICINE (2008)
Serum level of intercellular adhesion molecule-1 in children with malignant lymphoma
Nabil Abdelrazik et al.
MEDICAL PRINCIPLES AND PRACTICE (2008)
Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis
Eric A. Murphy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Cholestatic liver damage is mediated by lymphocyte function antigen-1-dependent recruitment of leukocytes
Stefan Dold et al.
SURGERY (2008)
Phase I and pharmacokinetic study of etaracizumab (Abegrin™), a humanized monoclonal antibody against αvβ3 integrin receptor, in patients with advanced solid tumors
Catherine Delbaldo et al.
INVESTIGATIONAL NEW DRUGS (2008)
Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system
Romain Cayrol et al.
NATURE IMMUNOLOGY (2008)
Interactions of tumor cells with dendritic cells: balancing immunity and tolerance
M. V. Dhodapkar et al.
CELL DEATH AND DIFFERENTIATION (2008)
A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth in vivo
Vinay Bhaskar et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2007)
Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses
Michael L. Dustin
CURRENT OPINION IN CELL BIOLOGY (2007)
Transforming growth factor-β and the immune response:: Implications for anticancer therapy
Stephen H. Wrzesinski et al.
CLINICAL CANCER RESEARCH (2007)
The oxidase activity of vascular adhesion protein-1 (VAP-1) induces endothelial E- and P-selectins and leukocyte binding
Sirpa Jalkanen et al.
BLOOD (2007)
Prostate cancer specific integrin αvβ3 modulates bone metastatic growth and tissue remodeling
N. P. McCabe et al.
ONCOGENE (2007)
CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation
Driss Ehirchiou et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
The role of vascular cell adhesion molecule-1 in tumor immune evasion
T-C. Wu
CANCER RESEARCH (2007)
A phase I trial of sorafenib (BAY 43-9006) for patients with recurrent or progressive malignant glioma (NABTT 0401)
L. B. Nabors et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
ICAM-1 expression determines malignant potential of cancer
Christina L. Roland et al.
SURGERY (2007)
Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development
Caroline Aspord et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
T-cell distribution and adhesion receptor expression in metastatic melanoma
Carsten Weishaupt et al.
CLINICAL CANCER RESEARCH (2007)
Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma
L. Burt Nabors et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
Phase I evaluation of a fully human anti-αv integrin monoclonal antibody (CNTO 95) in patients with advanced solid tumors
Saifee A. Mullamitha et al.
CLINICAL CANCER RESEARCH (2007)
αEβ7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis
Audrey Le Floc'h et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Integrin αvβ3 controls activity and oncogenic potential of primed c-Src
Stephan Huveneers et al.
CANCER RESEARCH (2007)
Activating Ly-49 receptors regulate LFA-1-mediated adhesion by NK cells
Mohammed S. Osman et al.
JOURNAL OF IMMUNOLOGY (2007)
Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation
Georg Varga et al.
BLOOD (2007)
Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma
Augusto C. Ochoa et al.
CLINICAL CANCER RESEARCH (2007)
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Klaus Ley et al.
NATURE REVIEWS IMMUNOLOGY (2007)
A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer
Helmut Friess et al.
BMC CANCER (2006)
Direct targeting of αvβ3 integrin on tumor cells with a monoclonal antibody, Abegrin™
Kathy Mulgrew et al.
MOLECULAR CANCER THERAPEUTICS (2006)
A novel anticancer effect of thalidomide:: Inhibition of intercellular adhesion molecule-1-mediated cell invasion and metastasis through suppression of nuclear factor-κB
Yi-Chu Lin et al.
CLINICAL CANCER RESEARCH (2006)
An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
Louise A. Johnson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade
Mia Phillipson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
Paolo Serafini et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Selectins and glycosyltransferases in leukocyte rolling in vivo
Markus Sperandio
FEBS JOURNAL (2006)
Activation of leukocyte β2 integrins by conversion from bent to extended conformations
Noritaka Nishida et al.
IMMUNITY (2006)
β4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis
Wenjun Guo et al.
CELL (2006)
The apoptotic-cell receptor CR3, but not ανβ5, is a regulator of human dendritic-cell immunostimulatory function
Mojca Skoberne et al.
BLOOD (2006)
Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2), a beta integrin antagonist, in patients with solid tumours
M. E. Cianfrocca et al.
BRITISH JOURNAL OF CANCER (2006)
Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors
Anita E. M. Dirkx et al.
FASEB JOURNAL (2006)
Anti-inflammatory - Efalizumab: a review of events reported during clinical trials and side effects
Noah Scheinfeld
EXPERT OPINION ON DRUG SAFETY (2006)
Integrin α4β1 promotes monocyte trafficking and angiogenesis in tumors
H Jin et al.
CANCER RESEARCH (2006)
The molecular basis of filamin binding to integrins and competition with talin
T Kiema et al.
MOLECULAR CELL (2006)
Differential mechanisms for T lymphocyte recruitment in normal and neoplastic human gastric mucosa
K Enarsson et al.
CLINICAL IMMUNOLOGY (2006)
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
E Sato et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
CD18 is required for optimal development and function of CD4+ CD25+ T regulatory cells
M Marski et al.
JOURNAL OF IMMUNOLOGY (2005)
Phase I trial of a monoclonal antibody specific for αvβ3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion
DG McNeel et al.
CLINICAL CANCER RESEARCH (2005)
Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
E Suzuki et al.
CLINICAL CANCER RESEARCH (2005)
Up regulation of ICAM-1 gene expression inhibits tumour growth and liver metastasis in colorectal carcinoma
A Tachimori et al.
EUROPEAN JOURNAL OF CANCER (2005)
Importance of integrin LFA-1 deactivation for the generation of immune responses
M Semmrich et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Distinct role of lymphocyte fuinction-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes
N Anikeeva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
ICAM-1 contributes to but is not essential for tumor antigen cross-priming and CD8+ T cell-mediated tumor rejection in vivo
C Blank et al.
JOURNAL OF IMMUNOLOGY (2005)
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells
J Huehn et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
The opsonin MFG-E8 is a ligand for the αvβ5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells
S Akakura et al.
EXPERIMENTAL CELL RESEARCH (2004)
Coupling tumor necrosis factor-α with αv integrin ligands improves its antineoplastic activity
F Curnis et al.
CANCER RESEARCH (2004)
LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivo
S Kandula et al.
JOURNAL OF IMMUNOLOGY (2004)
Human T regulatory cells can use the perforin pathway to cause autologous target cell death
WJ Grossman et al.
IMMUNITY (2004)
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
TJ Curiel et al.
NATURE MEDICINE (2004)
VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses
M Mittelbrunn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
L-Selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection
PA Taylor et al.
BLOOD (2004)
Integrin αv-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen
WJ Bao et al.
JOURNAL OF CELL BIOLOGY (2004)
CpG motifs as proinflammatory factors render autochthonous tumors permissive for infiltration and destruction
N Garbi et al.
JOURNAL OF IMMUNOLOGY (2004)
RIAM, an EnaNASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion
EM Lafuente et al.
DEVELOPMENTAL CELL (2004)
T-cell-antigen recognition and the immunological synapse
JB Huppa et al.
NATURE REVIEWS IMMUNOLOGY (2003)
Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins
M Kim et al.
SCIENCE (2003)
Paxillin binding to the α4 integrin subunit stimulates LFA-1 (integrin αLβ2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2
DM Rose et al.
JOURNAL OF IMMUNOLOGY (2003)
A role for class A scavenger receptor in dendritic cell nibbling from live cells
LA Harshyne et al.
JOURNAL OF IMMUNOLOGY (2003)
Anti-idiotype x anti-LFA-1 bispecific antibodies inhibit metastasis of B cell lymphoma
S Cohen et al.
JOURNAL OF IMMUNOLOGY (2003)
Selective in vivo growth of lymphocyte function-associated antigen-1-positive murine myeloma cells: Involvement of function-associated antigen-1-mediated homotypic cell-cell adhesion
K Asosingh et al.
EXPERIMENTAL HEMATOLOGY (2003)
Cadherin-mediated cell-cell adhesion: sticking together as a family
SD Patel et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2003)
Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7
I Verbovetski et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Cutting edge:: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
AP Kohm et al.
JOURNAL OF IMMUNOLOGY (2002)
Expression of the integrin αEβ7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells
J Lehmann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Role of integrins in cell invasion and migration
JD Hood et al.
NATURE REVIEWS CANCER (2002)
Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1
C Abraham et al.
JOURNAL OF IMMUNOLOGY (2001)
Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T cells is mediated by cell surface-bound transforming growth factor β
K Nakamura et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
Dendritic cells acquire antigens from live cells for cross-presentation to CTL
LA Harshyne et al.
JOURNAL OF IMMUNOLOGY (2001)
Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer
B Almand et al.
JOURNAL OF IMMUNOLOGY (2001)
T regulatory cells 1 inhibit a Th2-specific response in vivo
F Cottrez et al.
JOURNAL OF IMMUNOLOGY (2000)
Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins
K Tachibana et al.
JOURNAL OF CELL BIOLOGY (2000)
Tumor angiogenesis factors reduce leukocyte adhesion in vivo
SC Tromp et al.
INTERNATIONAL IMMUNOLOGY (2000)
CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen
PR Rogers et al.
JOURNAL OF IMMUNOLOGY (2000)
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