期刊
FRONTIERS IN IMMUNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01438
关键词
glucocorticoids; intestinal mucosa; intestinal immune homeostasis; inflammatory bowel disease; colorectal cancer; liver receptor homolog-1; tumor necrosis factor
类别
资金
- Ministry of Higher Education and Scientific Research, Sudan
- Baden-Wurttemberg-Stiftung
- German Science Foundation
Glucocorticoids (GCs) are steroid hormones predominantly produced in the adrenal glands in response to physiological cues and stress. Adrenal GCs mediate potent anti-inflammatory and immunosuppressive functions. Accumulating evidence in the past two decades has demonstrated other extra-adrenal organs and tissues capable of synthesizing GCs. This review discusses the role and regulation of GC synthesis in the intestinal epithelium in the regulation of normal immune homeostasis, inflammatory diseases of the intestinal mucosa, and the development of intestinal tumors.
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