期刊
CURRENT OSTEOPOROSIS REPORTS
卷 17, 期 4, 页码 195-206出版社
SPRINGER
DOI: 10.1007/s11914-019-00520-2
关键词
Osteocyte; Integrin; Mechanotransduction; Osteoporosis; Osteoarthritis; Bone metastasis
资金
- Science Foundation Ireland (SFI) [13/ERC/L2864, 12/RC/2278]
- European Regional Development Fund [13/RC/2073, 14/IA/2884]
- European Research Council (ERC) [336882, 258992]
- Science Foundation Ireland (SFI) [13/ERC/L2864] Funding Source: Science Foundation Ireland (SFI)
Purpose of ReviewOsteocytes are the main mechanosensitive cells in bone. Integrin-based adhesions have been shown to facilitate mechanotransduction, and therefore play an important role in load-induced bone formation. This review outlines the role of integrins in osteocyte function (cell adhesion, signalling, and mechanotransduction) and possible role in disease.Recent FindingsBoth beta(1) and beta(3) integrins subunits have been shown to be required for osteocyte mechanotransduction. Antagonism of these integrin subunits in osteocytes resulted in impaired responses to fluid shear stress. Various disease states (osteoporosis, osteoarthritis, bone metastases) have been shown to result in altered integrin expression and function.SummaryOsteocyte integrins are required for normal cell function, with dysregulation of integrins seen in disease. Understanding the mechanism of faulty integrins in disease may aid in the creation of novel therapeutic approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据