期刊
APPLIED SCIENCES-BASEL
卷 9, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/app9142886
关键词
polarimetry; light polarization; diattenuation; cancer cell; apoptosis
类别
资金
- Instituto de Investigacion Valdecilla (IDIVAL) [APG/03]
- SODERCAN (Sociedad para el Desarrollo de Cantabria)
- Research Vicerrectorate of the University of Cantabria [14JU2864661]
- University of Cantabria
Imaging polarimetry is a focus of increasing interest in diagnostic medicine because of its non-destructive nature and its potential to distinguish normal from tumor tissue. However, handling and understanding polarimetric images is not an easy task, and different intermediate steps have been proposed in order to introduce helpful physical magnitudes. In this research, we look for a sensitive polarimetric parameter that allows us to detect cell death when cancer cells are treated with chemotherapy drugs. Experiments in two different myelomonocytic leukemia cell lines, U937 and THP1, are performed in triplicate, finding a highly-significant positive correlation between total diattenuation of samples in transmission configuration, , and chemotherapy-induced cell death. The location of the diattenuation enhancement gives some insight into the cell death process. The proposed method can be an objective complement to conventional methodologies based on pure observational microscopy and can be easily implemented in regular microscopes.
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