期刊
ONCOLOGY RESEARCH AND TREATMENT
卷 42, 期 9, 页码 470-479出版社
KARGER
DOI: 10.1159/000501594
关键词
Esophageal cancer; Elective lymph node irradiation; Involved-field irradiation; Pattern of failure; Meta-analysis
类别
资金
- National Natural Science Foundation of China [81472809, 81502653, 81672983, 81703028]
- 333 Project of Jiangsu Province [BRA2012210]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) [JX10231801]
- Six Major Talent Peak Project of Jiangsu Province [2013-WSN-040]
Definitive radiotherapy has an affirmative role in treating non-operable esophageal cancer; however, the controversy between elective lymph node irradiation (ENI) and involved-field irradiation (IFI) still remains. To ascertain the benefits and disadvantages of the two radiation target volumes, we performed a meta-analysis with 7 related publications. According to our findings, patients treated with ENI and IFI had nearly identical 1, 2, and 3-year survival rates (pooled odds ratio [OR] = 1.004, p = 0.980, and pooled OR = 1.15, p = 0.594, and pooled OR = 0.918, p = 0.679, respectively). Likewise, no significant differences were detected in local recurrence rates (pooled OR = 1.04, p = 0.883), regional recurrence rates (pooled OR = 0.65, p = 0.555), and distant metastasis rates (pooled OR = 1.29, p = 0.309) between the two treatment groups. However, IFI could significantly decrease the incidences of acute radiation esophagitis (pooled OR = 2.30, p = 0.001) and late pneumonia (pooled OR = 2.52, p = 0.04) compared with ENI. This meta-analysis provides evidence that IFI is more feasible for non-operable esophageal cancer than ENI.
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