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YuKyung Lee et al.
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Byung-Hak Kim et al.
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Cheolhee Won et al.
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Camila D. Odio et al.
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Johanna A. Joyce et al.
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Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis
Veronica De Simone et al.
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Daiki Mochizuki et al.
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Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer
Ravi Thakur et al.
SCIENTIFIC REPORTS (2015)
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Alejandro V. Villarino et al.
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Jie Yuan et al.
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Wei Huang et al.
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Saara Aittomaki et al.
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Lucy Liu et al.
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Anne Schroeder et al.
CANCER RESEARCH (2014)
Changes in Signal Transducer and Activator of Transcription 3 (STAT3) Dynamics Induced by Complexation with Pharmacological Inhibitors of Src Homology 2 (SH2) Domain Dimerization
Diana Resetca et al.
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Lanxi Song et al.
JOURNAL OF THORACIC ONCOLOGY (2014)
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Sam Hanash et al.
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Glauben Landskron et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2014)
STAT3 Target Genes Relevant to Human Cancers
Richard L. Carpenter et al.
CANCERS (2014)
Targeted disruption of the JAK2/STAT3 pathway in combination with systemic administration of paclitaxel inhibits the priming of ovarian cancer stem cells leading to a reduced tumor burden
Khalid Abubaker et al.
FRONTIERS IN ONCOLOGY (2014)
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Xiaolei Zhang et al.
CANCER RESEARCH (2013)
Targeting the Tumor Microenvironment: From Understanding Pathways to Effective Clinical Trials
Hua Fang et al.
CANCER RESEARCH (2013)
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Ying-Mei Lin et al.
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Dziyana Kraskouskaya et al.
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Jo Meagan Garner et al.
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Caiyu Lin et al.
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Xiaoxia Sun et al.
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Shili Xu et al.
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Sangkil Nam et al.
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Daniela F. Quail et al.
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Gabriella Miklossy et al.
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John J. O'Shea et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
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Samuel Q. Li et al.
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Jian Yang et al.
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Douglas Hanahan et al.
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Interleukin-6 signaling pathway in targeted therapy for cancer
Yuqi Guo et al.
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Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion-induced acute lung injury
Takeshi Oyaizu et al.
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Challenges of genetic counseling in patients with autosomal dominant diseases, such as the hyper-IgE syndrome (STAT3-HIES)
Benedikt D. Spielberger et al.
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Role of Nitrative and Oxidative DNA Damage in Inflammation-Related Carcinogenesis
Mariko Murata et al.
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Frances R. Balkwill et al.
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Bikash Debnath et al.
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Xiaolei Zhang et al.
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Chang Ohk Sung et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Signal Transducer and Activator of Transcription 3 (Stat3C) Promotes Myeloid-Derived Suppressor Cell Expansion and Immune Suppression during Lung Tumorigenesis
Lingyan Wu et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
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Peter Friedl et al.
CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
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M. Zhao et al.
CURRENT MEDICINAL CHEMISTRY (2011)
Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors
Arun K. Mankan et al.
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Brian F. Zamarron et al.
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IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines
Wiltrud Lederle et al.
INTERNATIONAL JOURNAL OF CANCER (2011)
Involvement of interleukin-21 in the regulation of colitis-associated colon cancer
Carmine Stolfi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
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Paul A. Johnston et al.
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Current Status of Src Inhibitors in Solid Tumor Malignancies
Lauren N. Puls et al.
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Li Lin et al.
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Sergei I. Grivennikov et al.
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The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
Jan Brabek et al.
CELL COMMUNICATION AND SIGNALING (2010)
Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome
Cristina Woellner et al.
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Characterization of molecular recognition of STAT3 SH2 domain inhibitors through molecular simulation
In-Hee Park et al.
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Identification of a New Series of STAT3 Inhibitors by Virtual Screening
Kenji Matsuno et al.
ACS MEDICINAL CHEMISTRY LETTERS (2010)
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Li Lin et al.
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Yutaka Uehara et al.
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LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
B. Fuh et al.
BRITISH JOURNAL OF CANCER (2009)
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Flaubert Mbeunkui et al.
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IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway
Lin Wang et al.
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STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria
Lobelia Samavati et al.
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Deok-Hwan Yang et al.
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Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells
M. Walter et al.
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Hui Gao et al.
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Hua Yu et al.
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Adam W. Studebaker et al.
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Khandaker Al Zaid Siddiquee et al.
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Jared Wels et al.
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Alessandro Federico et al.
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STAT3 mutations in the hyper-IgE syndrome
Steven M. Holland et al.
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Uddalak Bharadwaj et al.
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Khandaker Siddiquee et al.
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Laurence Zitvogel et al.
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Jerom Galon et al.
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HT Lu et al.
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M Kortylewski et al.
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J Turkson et al.
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K Shuai et al.
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H Song et al.
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H Yu et al.
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MA Aller et al.
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Inhibitors of cytokine signal transduction
S Wormald et al.
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IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation
SJ Park et al.
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Mechanisms and functional significance of tumour-induced dendritic-cell defects
D Gabrilovich
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Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
TH Wang et al.
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Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells
C Buerger et al.
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LA Liotta et al.
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F Balkwill et al.
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The roles of the Drosophila JAK/STAT pathway
MP Zeidler et al.
ONCOGENE (2000)
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