期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 39, 期 12, 页码 1621-1627出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-016-0828-3
关键词
Marine fungus; Penicillium sclerotiorum; Penicilazaphilones; Antibacterial activity; Cytotoxicity
资金
- National Natural Science Foundation of China [81560484]
Two azaphilonidal derivatives [penicilazaphilones B (1) and C (2)], have been isolated from the fermented products of marine fungus strain Penicillium sclerotiorum M-22, penicilazaphilones C was a new compound. The compound's structures were identified by the analysis of spectroscopic data including 1D and 2D NMR techniques (H-1-NMR, C-13-NMR, COSY, HMQC, and HMBC). Biological evaluation revealed that penicilazaphilones B and C showed selective cytotoxicity against melanoma cells B-16 and human gastric cancer cells SGC-7901 with IC50 values of 0.291, 0.449 and 0.065, 0.720 mM, respectively, while exhibiting no significant toxicity to normal mammary epithelial cells M10 at the same concentration. Moreover, penicilazaphilones C also exhibited strong antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Escherichia coli with MIC values 0.037-0.150 mM, while penicilazaphilones B's bacteriostatic action was weaker.
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