Assessing the Effect of Vitamin D Replacement on Basal Cell Carcinoma Occurrence and Recurrence Rates in Patients with Vitamin D Deficiency

The study aimed to determine whether 25-OH vitamin D-3 deficiency is present in patients with diagnosed BCC, and the effect of vitamin D replacement on the rates of BCC recurrence in patients with 25-OH vitamin D-3 deficiency. In this prospective study, between 2012 and 2017, in the first stage, 25-OH vitamin D-3 levels of all patients diagnosed with BCC between 2012 and 2013 were evaluated. In the second stage between 2014 and 2015, we evaluated the 25-OH vitamin D-3 level of patients who had 25-OH vitamin D-3 level < 25 ng/mL. All the patients included in the second stage had BCC recurrence. In the third stage, the patients who were diagnosed 25-OH vitamin D-3 deficiency with BCC, between 2015 and 2017, were studied. The mean 25-OH vitamin D-3 level of the patients in the second stage was 10.12 ng/mL. Recurrence was observed in 9.64% of the patients in the second stage. The mean level of serum 25-OH vitamin D-3 in the third stage was 40.1 ng/mL, and 3.49% of these patients presented with recurrence. In all the patients as the initial diagnosis and following the 25-OH vitamin D-3 level in all the patients with BCC recurrence, maintaining 25-OH vitamin D-3 levels above 25 ng/mL can significantly reduce the recurrence rate.