期刊
CURRENT CARDIOLOGY REPORTS
卷 21, 期 8, 页码 -出版社
SPRINGER
DOI: 10.1007/s11886-019-1159-z
关键词
Low density; Lipoprotein; Cholesterol; Prevention; Cardiovascular disease; Coronary artery disease; Mendelian randomization; Statin
Purpose of ReviewLow-density lipoprotein cholesterol (LDL-C) is one major cause of cardiovascular disease (CVD). In this review, we discuss current developments in the understanding of LDL-C as lifelong risk factor, treatment targets, and emerging approaches to reduce cardiovascular risk by lowering LDL-C.Recent FindingsRecent evidence underscores the importance of LDL-C lowering in CVD prevention by mechanisms that increase the hepatic clearance of apolipoprotein B-containing lipoproteins from the plasma. Mendelian randomization studies provided evidence on both safety and efficacy of lower LDL-C in the long term. For young individuals, metrics other than 10-year CVD risk are required. Despite this evidence, LDL-C treatment target attainment is poor. Novel approaches are therefore needed. These include individualized strategies and new LDL-C-lowering pharmaceuticals.SummaryEarly, long-term treatment with LDL-C-lowering therapies has the potential to markedly reduce CVD incidence and progression. Future research should aim to identify patient characteristics that enable physicians to tailor therapy to each individual patient.
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