期刊
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
卷 127, 期 2, 页码 112-118出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13813455.2019.1620785
关键词
Oxidative stress; silymarin; TNF-α diclofenac; liver toxicity
The study demonstrated that silymarin has a protective effect on DIC-induced liver toxicity and oxidative stress in male rats, significantly improving related indicators and histopathological injuries.
Diclofenac (DIC) is a phenyl acetic acid derivative which is well known for its analgesic and anti-inflammatory. In our study, the rats were divided into four groups. Group 1, control group; Group 2 received DIC-only; Groups 3 and 4 received DIC plus silymarin. The results showed that levels of CAT, SOD, GPx and GSH significantly reduced and levels of ALT, AST, ALP, total bilirubin, nitrite content, MDA, serum TNF-alpha and TNF-alpha gene expression were significantly elevated in second group compared to control group. In other hand, treatment with silymarin resulted in a significant elevation in CAT, SOD, GPx, GSH and a significant reduction in MDA, ALT, AST, ALP, total bilirubin, nitrite content, serum TNF-alpha, and gene expression of TNF-alpha in comparison with second group. Histopathological injuries were also improved by silymarin administration. The results confirm that silymarin has a protective effect on DIC-induced liver toxicity and oxidative stress in male rats.
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