期刊
JAMA NEUROLOGY
卷 76, 期 11, 页码 1319-1329出版社
AMER MEDICAL ASSOC
DOI: 10.1001/jamaneurol.2019.2214
关键词
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资金
- ADNI (National) Institutes of Health [U01 AG024904]
- DOD ADNI (Department of Defense) [W81XWH-12-2-0012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- AbbVie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc
- Cogstate
- Eisai, Inc
- Elan Pharmaceuticals, Inc
- Eli Lilly and Company
- EuroImmun
- F. Hoffmann-La Roche, Ltd and its affiliated company Genentech, Inc
- Fujirebio
- GE Healthcare
- IXICO, Ltd
- Janssen Alzheimer Immunotherapy Research & Development, LLC
- Johnson & Johnson Pharmaceutical Research & Development, LLC
- Lumosity
- Lundbeck
- Merck Co, Inc
- Meso Scale Diagnostics, LLC
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer, Inc
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Canadian Institutes of Health Research
- Wallenberg Center for Molecular Medicine
- Lund University, Lund, Sweden
- European Research Council
- Swedish Research Council
- Knut and AliceWallenberg foundation
- Marianne and MarcusWallenberg foundation
- Strategic Research Area MultiPark (Multidisciplinary Research in Parkinson's disease) at Lund University
- Swedish Alzheimer Foundation
- Swedish Brain Foundation
- Parkinson foundation of Sweden
- Parkinson Research Foundation
- Skane University Hospital Foundation
- Swedish federal government under the ALF
IMPORTANCE Different brain regions appear to be involved during beta-amyloid (A beta) accumulation in Alzheimer disease (AD), but a longitudinally valid system to track A beta stages in vivo using positron emission tomography (PET) is lacking. OBJECTIVE To construct a longitudinally valid in vivo staging system for AD using amyloid PET. DESIGN, SETTING, AND PARTICIPANTS Longitudinal multicenter cohort study using data accessed on August 20, 2018, from the Alzheimer's Disease Neuroimaging Initiative database of scans performed from June 9, 2010, to July 12, 2018, from 741 persons: 304 without cognitive impairment, 384 with mild cognitive impairment, and 53 with AD dementia. Cerebrospinal fluid (CSF) A beta 42 and fluorine 18-labeled florbetapir (F-18-florbetapir) data were used to determine early, intermediate, and late regions of A beta accumulation. beta-Amyloid stages ranging from 0 to 3 were constructed using these composites. Each subsequent stage required involvement of more advanced regions. Patients were followed up at 2, 4, and 6 years. Replication and validation were conducted using an independent cohort (Swedish BioFINDER) and gene expression information from the Allen Human Brain Atlas database. Analyses were conducted August 21, 2018, to May 24, 2019. MAIN OUTCOMES AND MEASURES The main outcome was change in stage. Stages were compared for diagnosis, CSF biomarkers of tau, and longitudinal atrophy, cognitive measures, and regional gene expression. Transitions between stages were tested using longitudinal F-18-florbetapir data. RESULTS Among 641 participants with CSF A beta 42 data and at least two F-18-florbetapir scans, 335 (52.3%) were male. The early region of A beta accumulation included the precuneus, posterior cingulate, isthmus cingulate, insula, and medial and lateral orbitofrontal cortices. The late region included the lingual, pericalcarine, paracentral, precentral, and postcentral cortices. The intermediate region included remaining brain regions with increased accumulation rates. In 2072 PET scans from 741 participants, 2039 (98.4%) were unambiguously staged. At baseline, participants with stage 0 (n=402) had a 14.7% (95% CI, 11.2%-18.1%) probability of progression to a higher stage; stage 1 (n=21), 71.4% (95% CI, 50.0%-90.9%); and stage 2 (n=79), 53.1% (95% CI, 42.2%-64.0%). Seven of the 741 participants (0.9%) reverted to a lower stage. Higher stages were associated with lower CSF A beta 42 concentrations (from stage 1 at baseline), greater CSF P-tau (from stage 1) and CSF T-tau (from stage 2), and accelerated cognitive decline (from stage 2) and atrophy (from stage 3), even when adjusting for clinical diagnosis. Key findings were replicated in the BioFINDER cohort (N=474). The regions of different stages differed by gene expression profiles when using the transcriptome from the Allen Human Brain Atlas, especially involving genes associated with voltage-gated ion channel activity especially involving genes associated with voltage-gated ion channel activity, but also blood circulation, axon guidance, and lipid transportation. CONCLUSIONS AND RELEVANCE Results of this study suggest that this robust staging system of A beta accumulation may be useful for monitoring patients throughout the course of AD. Progression through stages may depend on underlying selective vulnerability in different brain regions.
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