期刊
JOURNAL OF THE AMERICAN HEART ASSOCIATION
卷 8, 期 12, 页码 -出版社
WILEY
DOI: 10.1161/JAHA.119.012406
关键词
cardiovascular disease outcomes; estrogen; menarche; risk factors; women
资金
- National Heart, Lung, and Blood Institute [N01-HV-68161, N01-HV-68162, N01-HV-68163, N01-HV-68164, K23-HL127262-01A1, K23-HL125941-01A1, U0164829, U01 HL649141, U01 HL649241, K23HL105787, T32HL69751, R01 HL090957]
- GCRC grant from the National Center for Research Resources [MO1-RR00425]
- National Center for Advancing Translational Sciences [UL1TR000124, UL1TR000064]
- Gustavus and Louis Pfeiffer Research Foundation, Danville, NJ,
- Women's Guild of Cedars-Sinai Medical Center, Los Angeles, CA
- Ladies Hospital Aid Society of Western Pennsylvania, Pittsburgh, PA
- QMED, Inc, Laurence Harbor, NJ
- Edythe L. Broad, Cedars-Sinai Medical Center, Los Angeles, CA
- Constance Austin Women's Heart Research Fellowships, Cedars-Sinai Medical Center, Los Angeles, CA
- Barbra Streisand Women's Cardiovascular Research and Education Program, Cedars-Sinai Medical Center, Los Angeles
- Society for Women's Health Research (SWHR), Washington, DC
- Linda Joy Pollin Women's Heart Health Program, Cedars-Sinai Medical Center, Los Angeles, CA
- Erika Glazer Women's Heart Health Project, Cedars-Sinai Medical Center, Los Angeles, CA
- National Institute on Aging [1R03AG032631]
Background-Previous studies have reported an association between the timing of menarche and cardiovascular disease (CVD). However, emerging studies have not examined the timing of menarche in relation to role of estrogen over a lifetime and major adverse cardiac events (MACE). Methods and Results-A total of 648 women without surgical menopause undergoing coronary angiography for suspected ischemia in the WISE (Women's lschemia Syndrome Evaluation) study were evaluated at baseline and followed for 6 years (median) to assess major adverse CVD outcomes. MACE was defined as the first occurrence of all-cause death, nonfatal myocardial infarction, nonfatal stroke, or heart failure hospitalization. Age at menarche was self-reported and categorized (<= 10, 11, 12, 13, 14, >= 15 years) with age 12 as reference. Total estrogen time and supra-total estrogen time were calculated. Cox regression analysis was performed adjusting for CVD risk factors. Baseline age was 57.9 +/- 12 years (mean +/- SD), body mass index was 29.5 +/- 6.5 kg/m(2), total estrogen time was 32.2 +/- 8.9 years, and supra-total estrogen time was 41.4 +/- 8.8 years. MACE occurred in 172 (27%), and its adjusted regression model was 1-shaped. Compared with women with menarche at age 12 years, the adjusted MACE hazard ratio for menarche at <= 10 years was 4.53 (95% CI 2.13-9.63); and at >= 15 years risk for MACE was 2.58 (95% CI, 1.28-5.21). Conclusions-History of early or late menarche was associated with a higher risk for adverse CVD outcomes. These findings highlight age at menarche as a potential screening tool for women at risk of adverse CVD events.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据