期刊
ARCHIVES OF ORAL BIOLOGY
卷 70, 期 -, 页码 62-66出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.archoralbio.2016.06.003
关键词
Dental caries; Children; Saliva; Oxidative stress; Superoxide dismutase; Uric acid
资金
- CAPES-PROAP and Programa de Pos-Graduacao em Ciencia Odontologica
- CAPES
Objective: This study aimed to evaluate the oxidative stress levels and the enzymatic and non-enzymatic antioxidant systems in saliva of toddlers with severe early childhood caries (S-ECC). Design: Unstimulated saliva samples were collected at the morning from 0 to 3 year-old S-ECC (n=30) or caries-free (CF) children (n = 30/group) for evaluation of oxidative stress (OS) and total antioxidant capacity (TAC), which were measured by the ferric reducing antioxidant power (FRAP) assay, as well as to assess the activity of enzymatic (superoxide dismutase, SOD) and non-enzymatic (uric acid, UA) antioxidant systems, respectively. Data were analyzed by Student's t-test (p < 0.05). Results: Significantly higher protein levels were observed in saliva of S-ECC children (0.083 mg/mL) than in the CF group (0.070 mg/mL). Oxidative damage was significantly lower in saliva of S-ECC children (0.0019 mu mol/L/mg protein) than in CF children (0.0039 mu mol/L/mg protein), while salivary TAC (61.5 mu mol/L), SOD activity (36.6 UE/mL) and uric acid (7.05 mg/mL) were significantly higher in saliva of S-ECC when compared to the CF group (49.1 mu mol/L, 26.8 UE/mL and 5.02 mg/mL, respectively for TAC, SOD and UA). Conclusion: Oxidative stress levels were significantly lower in saliva of S-ECC children, what might be associated with the increased activity of salivary enzymatic (SOD) and non-enzymatic (uric acid) antioxidant systems. (C) 2016 Elsevier Ltd. All rights reserved.
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