期刊
ELIFE
卷 8, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.43191
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资金
- National Natural Science Foundation of China [31525010, 31471049]
- Shanghai Municipal Science and Technology Commission [15JC1400102, 2018SHZDZX05, 16JC1400101]
- Ministerio de Ciencia, Innovacion y Universidades
- European Regional Development Fund [BFU2015-65318-R]
- CERCA Programme/Generalitat de Catalunya
- Chinese Academy of Agricultural Sciences [QYZDBSSW-SMC009, YZ201540]
Working memory is a critical brain function for maintaining and manipulating information over delay periods of seconds. It is debated whether delay-period neural activity in sensory regions is important for the active maintenance of information during the delay period. Here, we tackle this question by examining the anterior piriform cortex (APC), an olfactory sensory cortex, in head-fixed mice performing several olfactory working memory tasks. Active information maintenance is necessary in these tasks, especially in a dual-task paradigm in which mice are required to perform another distracting task while actively maintaining information during the delay period. Optogenetic suppression of neuronal activity in APC during the delay period impaired performance in all the tasks. Furthermore, electrophysiological recordings revealed that APC neuronal populations encoded odor information in the delay period even with an intervening distracting task. Thus, delay activity in APC is important for active information maintenance in olfactory working memory.
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