期刊
BIOMICROFLUIDICS
卷 9, 期 6, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.4935594
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资金
- RTI International internal RD funds
We report a microfluidic blood-brain barrier model that enables both physiological shear stress and optical transparency throughout the device. Brain endothelial cells grown in an optically transparent membrane-integrated microfluidic device were able to withstand physiological fluid shear stress using a hydrophilized polytetrafluoroethylene nanoporous membrane instead of the more commonly used polyester membrane. A functional three-dimensional microfluidic co-culture model of the neurovascular unit is presented that incorporates astrocytes in a 3D hydrogel and enables physiological shear stress on the membrane-supported endothelial cell layer. (C) 2015 AIP Publishing LLC.
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