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Microbiota-Derived Extracellular Vesicles as New Systemic Regulators
Sara Ahmadi Badi et al.
FRONTIERS IN MICROBIOLOGY (2017)
Valproic acid mitigates the inflammatory response and prevents acute respiratory distress syndrome in a murine model of Escherichia coli pneumonia at the expense of bacterial clearance
George Kasotakis et al.
Journal of Trauma and Acute Care Surgery (2017)
Antibiotics May Trigger Mitochondrial Dysfunction Inducing Psychiatric Disorders
George B. Stefano et al.
MEDICAL SCIENCE MONITOR (2017)
Lactoferrin in a Context of Inflammation-Induced Pathology
Marian L. Kruzel et al.
FRONTIERS IN IMMUNOLOGY (2017)
Heparin Mimics Extracellular DNA in Binding to Cell Surface-Localized Proteins and Promoting Staphylococcus aureus Biofilm Formation
Surabhi Mishra et al.
MSPHERE (2017)
Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling
Eva d'Hennezel et al.
MSYSTEMS (2017)
The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway
Pei Li et al.
SCIENTIFIC REPORTS (2017)
LPS-induced inflammatory response triggers cell cycle reactivation in murine neuronal cells through retinoblastoma proteins induction
Barbara D'Angelo et al.
CELL CYCLE (2017)
Activating α7 nicotinic acetylcholine receptor inhibits NLRP3 inflammasome through regulation of β-arrestin-1
Ping Ke et al.
CNS NEUROSCIENCE & THERAPEUTICS (2017)
5-fluorouracil causes endothelial cell senescence: potential protective role of glucagon-like peptide 1
Paola Altieri et al.
BRITISH JOURNAL OF PHARMACOLOGY (2017)
Alzheimer's disease and cytokine IL-10 gene polymorphism: is there an assocLtion?
Carolina Antunes Magalhaes et al.
ARQUIVOS DE NEURO-PSIQUIATRIA (2017)
Lactoferrin protects against intestinal inflammation and bacteria-induced barrier dysfunction in vitro
Nina A. Hering et al.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)
A New Treatment Strategy for Parkinson's Disease through the Gut-Brain Axis: The Glucagon-Like Peptide-1 Receptor Pathway
Dong Seok Kim et al.
CELL TRANSPLANTATION (2017)
Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake
Carlos Manlio Diaz-Garcia et al.
CELL METABOLISM (2017)
Loss of Brain Aerobic Glycolysis in Normal Human Aging
Manu S. Goyal et al.
CELL METABOLISM (2017)
Bacteria and endothelial cells: a toxic relationship
Ashira Lubkin et al.
CURRENT OPINION IN MICROBIOLOGY (2017)
Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation
Elizabeth A. Lendermon et al.
RESPIRATORY RESEARCH (2017)
Metabolic Adaptation Establishes Disease Tolerance to Sepsis
Sebastian Weis et al.
CELL (2017)
Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism
Rong Wang et al.
AGING CELL (2017)
Breast cancer and amyloid bodies: is there a role for amyloidosis in cancer-cell dormancy?
Gerald J. Mizejewski
BREAST CANCER-TARGETS AND THERAPY (2017)
Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?
Jodie Birch et al.
BIOESSAYS (2017)
Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype
Breno Satler Diniz et al.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2017)
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Marjolein P. Baar et al.
CELL (2017)
Lactate in the brain: an update on its relevance to brain energy, neurons, glia and panic disorder
Laurel Riske et al.
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (2017)
Re-expression of cell cycle markers in aged neurons and muscles: Whether cells should divide or die?
Renu Sharma et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)
Heparan sulfation is essential for the prevention of cellular senescence
S. H. Jung et al.
CELL DEATH AND DIFFERENTIATION (2016)
PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease
Patricia Martin-Maestro et al.
HUMAN MOLECULAR GENETICS (2016)
Intestinal M cells
Hiroshi Ohno
JOURNAL OF BIOCHEMISTRY (2016)
The pathogenic role of the inflammasome in neurodegenerative diseases
Leslie C. Freeman et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage
Jianru Li et al.
MOLECULAR NEUROBIOLOGY (2016)
SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation
Ganye Zhao et al.
AGING-US (2016)
Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity
Shobhit Dhawan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)
The Warburg effect: 80 years on
Michelle Potter et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2016)
Mitophagy: a balance regulator of NLRP3 inflammasome activation
Min-Ji Kim et al.
BMB REPORTS (2016)
Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study
Toshitaka Odamaki et al.
BMC MICROBIOLOGY (2016)
Intrinsic Defense Mechanisms of the Intestinal Epithelium
Deepshika Ramanan et al.
CELL HOST & MICROBE (2016)
NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Evandro Fei Fang et al.
CELL METABOLISM (2016)
Aging-dependent decline of IL-10 producing B cells coincides with production of antinuclear antibodies but not rheumatoid factors
Kornelis S. M. van der Geest et al.
EXPERIMENTAL GERONTOLOGY (2016)
Activation of the NLRP3 inflammasome by cellular labile iron
Kyohei Nakamura et al.
EXPERIMENTAL HEMATOLOGY (2016)
Dark microglia: A new phenotype predominantly associated with pathological states
Kanchan Bisht et al.
GLIA (2016)
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease
John Attanasio et al.
IMMUNITY (2016)
Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression
Ren-Hong Du et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2016)
Autophagy as a target for therapeutic uses of multifunctional peptides
Gabriel Mucino et al.
IUBMB LIFE (2016)
Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model
Karine Bourgade et al.
JOURNAL OF ALZHEIMERS DISEASE (2016)
Microbes and Alzheimer's Disease
Ruth F. Itzhaki et al.
JOURNAL OF ALZHEIMERS DISEASE (2016)
Heme Synthesis and Acquisition in Bacterial Pathogens
Jacob E. Choby et al.
JOURNAL OF MOLECULAR BIOLOGY (2016)
Aerobic glycolysis during brain activation: adrenergic regulation and influence of norepinephrine on astrocytic metabolism
Gerald A. Dienel et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
Jin Liu et al.
JOURNAL OF NEUROINFLAMMATION (2016)
Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease
Julien Couturier et al.
JOURNAL OF NEUROINFLAMMATION (2016)
Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain
Fengjiao Wu et al.
JOURNAL OF NEUROINFLAMMATION (2016)
Cdk5-Dependent Activation of Neuronal Inflammasomes in Parkinson's Disease
Pei Zhang et al.
MOVEMENT DISORDERS (2016)
BEYOND NEUROVASCULAR COUPLING, ROLE OF ASTROCYTES IN THE REGULATION OF VASCULAR TONE
J. A. Filosa et al.
NEUROSCIENCE (2016)
Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes
Ines G. Mollet et al.
PLOS ONE (2016)
Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease
Deepak Kumar Vijaya Kumar et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown
Yu Yamazaki et al.
STROKE (2016)
Mitochondrial Dysfunction Meets Senescence
Suchira Gallage et al.
TRENDS IN BIOCHEMICAL SCIENCES (2016)
Inhibition of herpes virus infection in oligodendrocyte cultured cells by valproic acid
A. J. Crespillo et al.
VIRUS RESEARCH (2016)
Alterations in Mitochondria! Quality Control in Alzheimer's Disease
Qian Cai et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2016)
Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
Poomy Pandey et al.
ONCOTARGET (2016)
Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence
Elizabeth P. Crowe et al.
FRONTIERS IN AGING NEUROSCIENCE (2016)
Low-Dose Lithium Stabilizes Human Endothelial Barrier by Decreasing MLC Phosphorylation and Universally Augments Cholinergic Vasorelaxation Capacity in a Direct Manner
Bert Bosche et al.
FRONTIERS IN PHYSIOLOGY (2016)
Lactate Contribution to the Tumor Microenvironment: Mechanisms, effects on immune Cells and Therapeutic Relevance
Susana Romero-Garcia et al.
FRONTIERS IN IMMUNOLOGY (2016)
New insights into Regulatory T Cells: exosome- and Non-Coding RNA-Mediated Regulation of Homeostasis and Resident Treg Cells
Peiyao Li et al.
FRONTIERS IN IMMUNOLOGY (2016)
Microbial regulation of GLP-1 and L-cell biology
Thomas U. Greiner et al.
MOLECULAR METABOLISM (2016)
Anti-inflammatory and Immunomodulatory Effects of Antibiotics and Their Use in Dermatology
Swetalina Pradhan et al.
INDIAN JOURNAL OF DERMATOLOGY (2016)
Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner
Agustina Errea et al.
PLOS ONE (2016)
Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model
Sheng Fong et al.
SCIENTIFIC REPORTS (2016)
Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity
Philipp Spitzer et al.
SCIENTIFIC REPORTS (2016)
Minocycline induces protective autophagy in vascular endothelial cells exposed to an in vitro model of ischemia/reperfusion-induced injury
Wenbin Dong et al.
BIOMEDICAL REPORTS (2016)
Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's disease
Lucie A. G. van Leeuwen et al.
ACTA NEUROPATHOLOGICA (2015)
From cellular senescence to Alzheimer's disease: The role of telomere shortening
Virginia Boccardi et al.
AGEING RESEARCH REVIEWS (2015)
Rifampicin reduces advanced glycation end products and activates DAF-16 to increase lifespan in Caenorhabditis elegans
Sandeep Golegaonkar et al.
AGING CELL (2015)
Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation
Inhwa Hwang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Donepezil attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells through SIRT1 activation
Tao Zhang et al.
CELL STRESS & CHAPERONES (2015)
GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R
Bernardo Yusta et al.
DIABETES (2015)
Intestinal mTOR regulates GLP-1 production in mouse L cells
Geyang Xu et al.
DIABETOLOGIA (2015)
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Bennett G. Childs et al.
NATURE MEDICINE (2015)
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson's Disease
Alicia M. Pickrell et al.
NEURON (2015)
Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
Axel Montagne et al.
NEURON (2015)
The early synthesis of p35 and activation of CDK5 in LPS-stimulated macrophages suppresses interleukin-10 production
Yi Rang Na et al.
SCIENCE SIGNALING (2015)
Mitochondria: diversity in the regulation of the NLRP3 inflammasome
Prajwal Gurung et al.
TRENDS IN MOLECULAR MEDICINE (2015)
Role of the normal gut microbiota
Sai Manasa Jandhyala et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2015)
Legal but lethal: functional protein aggregation at the verge of toxicity
Angelika Falsone et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2015)
Duodenal Cytochrome b (DCYTB) in Iron Metabolism: An Update on Function and Regulation
Darius J. R. Lane et al.
NUTRIENTS (2015)
Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)
Janette Bester et al.
ONCOTARGET (2015)
Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation
Roberto Piacentini et al.
SCIENTIFIC REPORTS (2015)
Microglial cell dysregulation in brain aging and neurodegeneration
Rommy von Bernhardi et al.
FRONTIERS IN AGING NEUROSCIENCE (2015)
Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains
Diane M. Bushman et al.
ELIFE (2015)
The early synthesis of p35 and activation of CDK5 in LPS-stimulated macrophages suppresses interleukin-10 production
Yi Rang Na et al.
SCIENCE SIGNALING (2015)
Immune aging, dysmetabolism, and inflammation in neurological diseases
Michela Deleidi et al.
FRONTIERS IN NEUROSCIENCE (2015)
Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect
Lloyd A. Demetrius et al.
FRONTIERS IN PHYSIOLOGY (2015)
Exosomes in the thymus: antigen transfer and vesicles
Gabriel Skogberg et al.
FRONTIERS IN IMMUNOLOGY (2015)
Aerobic glycolysis: beyond proliferation
William Jones et al.
FRONTIERS IN IMMUNOLOGY (2015)
Biofilm-associated bacterial amyloids dampen inflammation in the gut: oral treatment with curli fibres reduces the severity of hapten-induced colitis in mice
Gertrude O. Oppong et al.
NPJ BIOFILMS AND MICROBIOMES (2015)
β-Amyloid peptides display protective activity against the human Alzheimer's disease-associated herpes simplex virus-1
Karine Bourgade et al.
BIOGERONTOLOGY (2015)
Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review
Shintaro Sato et al.
GERONTOLOGY (2015)
Distinct Chronology of Neuronal Cell Cycle Re-Entry and Tau Pathology in the 3xTg-AD Mouse Model and Alzheimer's Disease Patients
Alex C. Hradek et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
The Characterization of Novel Tissue Microbiota Using an Optimized 16S Metagenomic Sequencing Pipeline
Jerome Lluch et al.
PLOS ONE (2015)
Fimbriae-mediated outer membrane vesicle production and invasion of Porphyromonas gingivalis
Chinmay K. Mantri et al.
MICROBIOLOGYOPEN (2015)
Characterization of ATP Alternations in an Alzheimer's Disease Transgenic Mouse Model
Cheng Zhang et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Regulation of the Intestinal Barrier Function by Host Defense Peptides
Kelsy Robinson et al.
FRONTIERS IN VETERINARY SCIENCE (2015)
Lithium and Autophagy
Yumiko Motoi et al.
ACS CHEMICAL NEUROSCIENCE (2014)
The role of microglia in human disease: therapeutic tool or target?
Nathalie Cartier et al.
ACTA NEUROPATHOLOGICA (2014)
Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells
Yu-Fan Chuang et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Microglial dysfunction in brain aging and Alzheimer's disease
Kira Irving Mosher et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Are there roles for brain cell senescence in aging and neurodegenerative disorders?
Florence C. C. Tan et al.
BIOGERONTOLOGY (2014)
Enteral supplementation of bovine lactoferrin improves gut barrier function in rats after massive bowel resection
Jiang Wu et al.
BRITISH JOURNAL OF NUTRITION (2014)
Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival
Christina L. Roland et al.
CANCER RESEARCH (2014)
Gut Dysbiosis and Detection of Live Gut Bacteria in Blood of Japanese Patients With Type 2 Diabetes
Junko Sato et al.
DIABETES CARE (2014)
Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor- and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity
Rafaz Hoque et al.
GASTROENTEROLOGY (2014)
Polysaccharide A of Bacteroides fragilis: Actions on Dendritic Cells and T Cells
Hisako Kayama et al.
MOLECULAR CELL (2014)
The role of iron in brain ageing and neurodegenerative disorders
Roberta Ward et al.
LANCET NEUROLOGY (2014)
Inflammasomes in the CNS
John G. Walsh et al.
NATURE REVIEWS NEUROSCIENCE (2014)
Bovine Lactoferrin Induces Cell Cycle Arrest and Inhibits Mtor Signaling in Breast Cancer Cells
Yunlei Zhang et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2014)
Elevated Levels of Circulating DNA in Cardiovascular Disease Patients: Metagenomic Profiling of Microbiome in the Circulation
Vasudevan Dinakaran et al.
PLOS ONE (2014)
Interleukin-1β Induces Blood-Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes
Yue Wang et al.
PLOS ONE (2014)
Azithromycin suppresses CD4+ T-cell activation by direct modulation of mTOR activity
F. Ratzinger et al.
SCIENTIFIC REPORTS (2014)
Pathogenic microbes, the microbiome, and Alzheimer's disease (AD)
James M. Hill et al.
FRONTIERS IN AGING NEUROSCIENCE (2014)
Mitochondria-mediated apoptosis in mammals
Shunbin Xiong et al.
PROTEIN & CELL (2014)
Aging of the Nitric Oxide System: Are We as Old as Our NO?
Aaron L. Sverdlov et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2014)
Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease
Gary P. Morris et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)
Pericytes: brain-immune interface modulators
Gabriela Hurtado-Alvarado et al.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE (2014)
Effect of chronic treatment with lithium on protein cyclin-dependent kinase 5 (CDK5) and tau protein in a primary culture of cortical neurons
Marília Carvalho et al.
Alzheimers & Dementia (2013)
Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock
Kairui Mao et al.
CELL RESEARCH (2013)
Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases
R. M. Naylor et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)
Loss of iron triggers PINK1/Parkin-independent mitophagy
George F. G. Allen et al.
EMBO REPORTS (2013)
Assessing and Treating Forgetfulness and Cognitive Problems in Adults With HIV
David E. Vance et al.
JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE (2013)
The CD226/CD155 Interaction Regulates the Proinflammatory (Th1/Th17)/Anti-Inflammatory (Th2) Balance in Humans
Ester Lozano et al.
JOURNAL OF IMMUNOLOGY (2013)
Heparin blocks transfer of extracellular vesicles between donor and recipient cells
Nadia A. Atai et al.
JOURNAL OF NEURO-ONCOLOGY (2013)
Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology
Susan A. Austin et al.
JOURNAL OF NEUROCHEMISTRY (2013)
Sustained Interleukin-1β Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model
Simantini Ghosh et al.
JOURNAL OF NEUROSCIENCE (2013)
Normal cognition in transgenic BRI2-Aβ mice
Jungsu Kim et al.
MOLECULAR NEURODEGENERATION (2013)
Gingipain-dependent degradation of mammalian target of rapamycin pathway proteins by the periodontal pathogen Porphyromonas gingivalis during invasion
P. Stafford et al.
MOLECULAR ORAL MICROBIOLOGY (2013)
The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice
A. Kobayashi et al.
MUCOSAL IMMUNOLOGY (2013)
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
Michael T. Heneka et al.
NATURE (2013)
Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota
Anna Cebula et al.
NATURE (2013)
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
Charleen T. Chu et al.
NATURE CELL BIOLOGY (2013)
Innate Regeneration in the Aging Heart: Healing From Within
Piero Anversa et al.
MAYO CLINIC PROCEEDINGS (2013)
Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain
Chuang Guo et al.
NEUROCHEMISTRY INTERNATIONAL (2013)
TREM2 Variants in Alzheimer's Disease
Rita Guerreiro et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Natural IgG Autoantibodies Are Abundant and Ubiquitous in Human Sera, and Their Number Is Influenced By Age, Gender, and Disease
Eric P. Nagele et al.
PLOS ONE (2013)
Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells
Thomas Secher et al.
PLOS ONE (2013)
Oncogene-induced cellular senescence elicits an anti-Warburg effect
Mingxi Li et al.
PROTEOMICS (2013)
Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells
Sameer Kalghatgi et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Tolerance has its limits: how the thymus copes with infection
Claudio Nunes-Alves et al.
TRENDS IN IMMUNOLOGY (2013)
Evidence for impaired amyloid beta clearance in Alzheimer's disease
Kristin R. Wildsmith et al.
ALZHEIMERS RESEARCH & THERAPY (2013)
The effect of aging of the immune system on vaccination responses
Janet M. Lord
HUMAN VACCINES & IMMUNOTHERAPEUTICS (2013)
NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
Carmela R. Balistreri et al.
IMMUNITY & AGEING (2013)
Risk Factors for β-Amyloid Deposition in Healthy Aging
Karen M. Rodrigue et al.
JAMA NEUROLOGY (2013)
A senescent cell bystander effect: senescence-induced senescence
Glyn Nelson et al.
AGING CELL (2012)
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
Diana Jurk et al.
AGING CELL (2012)
Antibacterial Activities of Iron Chelators against Common Nosocomial Pathogens
Mitchell G. Thompson et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Dianne H. Dapito et al.
CANCER CELL (2012)
mTOR Regulates Cellular Iron Homeostasis through Tristetraprolin
Marina Bayeva et al.
CELL METABOLISM (2012)
IQGAP1 mediates the disruption of adherens junctions to promote Escherichia coli K1 invasion of brain endothelial cells
Subramanian Krishnan et al.
CELLULAR MICROBIOLOGY (2012)
DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out
Kevin W. McCool et al.
IMMUNOLOGICAL REVIEWS (2012)
E-Selectin Mediates Porphyromonas gingivalis Adherence to Human Endothelial Cells
Toshinori Komatsu et al.
INFECTION AND IMMUNITY (2012)
Lactoferrin-lipopolysaccharide (LPS) binding as key to antibacterial and antiendotoxic effects
Maria Elisa Drago-Serrano et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2012)
Innate immunity in the central nervous system
Richard M. Ransohoff et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells
Elina M. Sutinen et al.
JOURNAL OF NEUROINFLAMMATION (2012)
Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus
Donald J. Alcendor et al.
JOURNAL OF NEUROINFLAMMATION (2012)
LPS-binding Protein Enables Intestinal Epithelial Restitution Despite LPS Exposure
Juli M. Richter et al.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2012)
Infectious Agents and Neurodegeneration
Giovanna De Chiara et al.
MOLECULAR NEUROBIOLOGY (2012)
A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation?
Haitao Wen et al.
NATURE IMMUNOLOGY (2012)
Anti-Inflammatory Properties of Sirtuin 6 in Human Umbilical Vein Endothelial Cells
Martha Lappas
MEDIATORS OF INFLAMMATION (2012)
Repeated Lipopolysaccharide Stimulation Induces Cellular Senescence in BV2 Cells
Hong-Mei Yu et al.
NEUROIMMUNOMODULATION (2012)
Do beta-Defensins and Other Antimicrobial Peptides Play a Role in Neuroimmune Function and Neurodegeneration?
Wesley M. Williams et al.
SCIENTIFIC WORLD JOURNAL (2012)
The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence
Yun-Hee Youm et al.
CELL REPORTS (2012)
Epidemiology of Alzheimer Disease
Richard Mayeux et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration
Jonas J. Neher et al.
FRONTIERS IN PHARMACOLOGY (2012)
Alzheimer's disease, neuroprotection, and CNS immunosenescence
Wolfgang J. Streit et al.
FRONTIERS IN PHARMACOLOGY (2012)
Immune Disorders and Its Correlation with Gut Microbiome
Ji-Sun Hwang et al.
Immune Network (2012)
Antibiofilm Effects of Azithromycin and Erythromycin on Porphyromonas gingivalis
H. Maezono et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Iron mediates endothelial cell damage and blood-brain barrier opening in the hippocampus after transient forebrain ischemia in rats
Sun Mi Won et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2011)
Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis
Pedro Bullon et al.
FREE RADICAL BIOLOGY AND MEDICINE (2011)
Aging correlates with reduction in regulatory-type cytokines and T cells in the gut mucosa
Andrezza F. Santiago et al.
IMMUNOBIOLOGY (2011)
Molecular mechanisms of inflammasome activation during microbial infections
Petr Broz et al.
IMMUNOLOGICAL REVIEWS (2011)
SIRT1 Regulation of Wakefulness and Senescence-Like Phenotype in Wake Neurons
Lori Panossian et al.
JOURNAL OF NEUROSCIENCE (2011)
Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut
N. J. Mantis et al.
MUCOSAL IMMUNOLOGY (2011)
Peripheral education of the immune system by colonic commensal microbiota
Stephanie K. Lathrop et al.
NATURE (2011)
Age-related changes in Arc transcription and DNA methylation within the hippocampus
M. R. Penner et al.
NEUROBIOLOGY OF AGING (2011)
Targeting HDACs: A Promising Therapy for Alzheimer's Disease
Ke Xu et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2011)
Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease
L. Crews et al.
CELL DEATH & DISEASE (2011)
Human Immunodeficiency Virus-Associated Neurocognitive Disorders Mind the Gap
Justin C. McArthur et al.
ANNALS OF NEUROLOGY (2010)
Infectious Burden and Risk of Stroke The Northern Manhattan Study
Mitchell S. V. Elkind et al.
ARCHIVES OF NEUROLOGY (2010)
Interleukin-18, From Neuroinflammation to Alzheimer's Disease
Paola Bossu et al.
CURRENT PHARMACEUTICAL DESIGN (2010)
Lipofuscin-bound iron is a major intracellular source of oxidants: Role in senescent cells
Annika Hoehn et al.
FREE RADICAL BIOLOGY AND MEDICINE (2010)
A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease
Renato X. Santos et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Mitochondrial Iron Metabolism and Its Role in Neurodegeneration
Maxx P. Horowitz et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
p35 Is Required for CDK5 Activation in Cellular Senescence
Daqin Mao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling
Hana Blazkova et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)
Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21
Yasuhiro Saito et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells
Walter J. Lukiw et al.
NEUROREPORT (2010)
Antimicrobial properties of lactoferrin
Havard Jenssen et al.
BIOCHIMIE (2009)
Debris clearance by microglia: an essential link between degeneration and regeneration
H. Neumann et al.
BRAIN (2009)
Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease
Jin-Tai Yu et al.
BRAIN RESEARCH (2009)
Pseudomonas pyocyanin inhibits wound repair by inducing premature cellular senescence: Role for p38 mitogen-activated protein kinase
Michael Muller et al.
BURNS (2009)
The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1
Junko H. Ohyashiki et al.
CANCER SCIENCE (2009)
Responses to Amyloids of Microbial and Host Origin Are Mediated through Toll-like Receptor 2
Cagla Tuekel et al.
CELL HOST & MICROBE (2009)
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients
Johanna Ojala et al.
NEUROBIOLOGY OF AGING (2009)
Crosstalk between Cdk5 and GSK3 beta: implications for Alzheimer's disease
Olivia Engmann et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2009)
Possible role of amyloid-beta, adenine nucleotide translocase and cyclophilin-D interaction in mitochondrial dysfunction of Alzheimer's disease
Prabhakar Singh et al.
BIOINFORMATION (2009)
Ecological role of lactobacilli in the gastrointestinal tract: Implications for fundamental and biomedical research
Jens Walter
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2008)
Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction
Atsunori Nakao et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Studies on anticancer activities of antimicrobial peptides
David W. Hoskin et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)
Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease
Yi Li et al.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2008)
Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity
Kryslaine O. Lopes et al.
GLIA (2008)
Human postmortem brain-derived cerebrovascular smooth muscle cells express all genes of the classical complement pathway: A potential mechanism for vascular damage in cerebral amyloid angiopathy and Alzheimer's disease
Douglas G. Walker et al.
MICROVASCULAR RESEARCH (2008)
Mechanisms of microbial traversal of the blood-brain barrier
Kwang Sik Kim
NATURE REVIEWS MICROBIOLOGY (2008)
Cellular senescence and organismal aging
Jessie C. Jeyapalan et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2008)
Nitric oxide and endothelial cellular senescence
Toshio Hayashi et al.
PHARMACOLOGY & THERAPEUTICS (2008)
Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons
Jie Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells
Henrik Suttmann et al.
BMC Urology (2008)
Rapamycin modulates the eNOS vs. shear stress relationship
Caroline Cheng et al.
CARDIOVASCULAR RESEARCH (2008)
Effects of defensin and lactoferrin on functional activity of endothelial cells in vitro
A. V. Krylov et al.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2007)
Characterization of heme as activator of toll-like receptor 4
Rodrigo T. Figueiredo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
IL-1β causes an increase in intestinal epithelial tight junction permeability
Rana M. Al-Sadi et al.
JOURNAL OF IMMUNOLOGY (2007)
Evidence that aging and amyloid promote microglial cell senescence
Barry E. Flanary et al.
REJUVENATION RESEARCH (2007)
Microglia derived from aging mice exhibit an altered inflammatory profile
Amanda Sierra et al.
GLIA (2007)
Amyloid, hypometabolism, and cognition in Alzheimer disease - An [11C]PIB and [18F]FDG PET study
P. Edison et al.
NEUROLOGY (2007)
Astrocytes are active players in cerebral innate immunity
Cinthia Farina et al.
TRENDS IN IMMUNOLOGY (2007)
FDA approval summary: Vorinostat for treatment of advanced primary cutaneous T-cell lymphoma
Bhupinder S. Mann et al.
ONCOLOGIST (2007)
IL-1β regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program
Azeb Tadesse Argaw et al.
JOURNAL OF IMMUNOLOGY (2006)
Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity
Gerty Schreibelt et al.
JOURNAL OF IMMUNOLOGY (2006)
Interleukin-1 mediates Alzheimer and Lewy body pathologies
W. Sue T. Griffin et al.
JOURNAL OF NEUROINFLAMMATION (2006)
Involvement of intestinal dendritic cells in oral tolerance, immunity to pathogens, and inflammatory bowel disease
BL Kelsall et al.
IMMUNOLOGICAL REVIEWS (2005)
p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death
M Hamdane et al.
JOURNAL OF CELL SCIENCE (2005)
Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium
EG Jorda et al.
NEUROSCIENCE (2005)
Acute-phase concentrations of lipopolysaccharide (LPS)-binding protein inhibit innate immune cell activation by different LPS chemotypes via different mechanisms
L Hamann et al.
INFECTION AND IMMUNITY (2005)
Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
M Ingelsson et al.
NEUROLOGY (2004)
Cell cycle activation linked to neuronal cell death initiated by DNA damage
II Kruman et al.
NEURON (2004)
Involvement of IL-1 family proteins in p38 linked cellular senescence of mouse embryonic fibroblasts
N Uekawa et al.
FEBS LETTERS (2004)
Iron accumulation during cellular senescence in human fibroblasts in vitro
DW Killilea et al.
ANTIOXIDANTS & REDOX SIGNALING (2003)
Effect of hydroxamic acid-based matrix metalloproteinase inhibitors on human gingival cells and Porphyromonas gingivalis
M Yoshioka et al.
JOURNAL OF PERIODONTOLOGY (2003)
Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
JM Orgogozo et al.
NEUROLOGY (2003)
Demystified ... Human endogenous retroviruses
PN Nelson et al.
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY (2003)
Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactions
H Kato et al.
INTERNATIONAL IMMUNOLOGY (2003)
Lipopolysaccharide-induced apoptosis of endothelial cells and its inhibition by vascular endothelial growth factor
N Munshi et al.
JOURNAL OF IMMUNOLOGY (2002)
Evidence for early aging in the mucosal immune system
T Koga et al.
JOURNAL OF IMMUNOLOGY (2000)
Melatonin is responsible for the nocturnal increase observed in serum and thymus of thymosin alpha(1) and thymulin concentrations: observations in rats and humans
P Molinero et al.
JOURNAL OF NEUROIMMUNOLOGY (2000)
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