期刊
BALKAN MEDICAL JOURNAL
卷 36, 期 5, 页码 283-286出版社
GALENOS PUBL HOUSE
DOI: 10.4274/balkanmedj.galenos.2019.2018.12.93
关键词
Chemoradiotherapy; O6-methylguanine-DNA methyltransferase; rectal adenocarcinoma
Aims: To analyze the clinical relevance of O6-methylguanineDNA methyltransferase in rectal adenocarcinoma treated with chemoradiotherapy followed by surgery. Methods: Tissue samples from 29 rectal adenocarcinoma patients were obtained after chemoradiotherapy. O6-methylguanine-DNA methyltransferase promoter methylation status was established by methylation-specific polymerase chain reaction. O6-methylguanine-DNA methyltransferase protein levels were determined by immunohistochemistry. Clinicopathologic variables, including treatment regression grade, recurrence, lymph node invasion, and stage and differentiation grade of the tumor, were determined. Results: The O6-methylguanine-DNA methyltransferasc gene promoter was methylated in 81.5% of samples. Most patients (88.9%) showed low O6-methylguanine-DNA methyltransferase protein expression. O6-methylguanine-DNA methyltransferase methylation status was not correlated with any of the clinicopathological variables determined in rectal adenocarcinomas selected for chemoradiotherapy. Conclusion: O6-methylguanine-DNA methyltransferase methylation status is not correlated with clinicopathologic variables examined in rectal adenocarcinoma selected for chemoradiotherapy. although its role as a biomarker awaits further investigation.
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