相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
Demis Menolfi et al.
NATURE COMMUNICATIONS (2018)
Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM
Yi Zhou et al.
MOLECULAR CELL (2017)
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
Andrew N. Blackford et al.
MOLECULAR CELL (2017)
The control of DNA repair by the cell cycle
Nicole Hustedt et al.
NATURE CELL BIOLOGY (2017)
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
Bancinyane L. Sibanda et al.
SCIENCE (2017)
Ewing Tumor-associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks
Sumin Feng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage
Ana Finzel et al.
MOLECULAR BIOLOGY OF THE CELL (2016)
Two-Stage Synapsis of DNA Ends during Non-homologous End Joining
Thomas G. W. Graham et al.
MOLECULAR CELL (2016)
ETAA1 acts at stalled replication forks to maintain genome integrity
Thomas E. Bass et al.
NATURE CELL BIOLOGY (2016)
Activation of the ATR kinase by the RPA-binding protein ETAA1
Peter Haahr et al.
NATURE CELL BIOLOGY (2016)
Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers
Petra Schwertman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
53BP1 fosters fidelity of homology-directed DNA repair
Fena Ochs et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Repair Pathway Choices and Consequences at the Double-Strand Break
Raphael Ceccaldi et al.
TRENDS IN CELL BIOLOGY (2016)
53BP1 fosters fidelity of homology-directed DNA repair
Fena Ochs et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Mechanisms of ATM Activation
Tanya T. Paull
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 84 (2015)
Molecular Pathways: Targeting ATR in Cancer Therapy
Larry M. Karnitz et al.
CLINICAL CANCER RESEARCH (2015)
The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function
Lian Xue et al.
DNA REPAIR (2015)
Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase
Remi Buisson et al.
MOLECULAR CELL (2015)
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis
Nicholas Jette et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2015)
Targeting ATR in DNA damage response and cancer therapeutics
Emmanouil Fokas et al.
CANCER TREATMENT REVIEWS (2014)
Functional overlaps between XLF and the ATM-dependent DNA double strand break response
Vipul Kumar et al.
DNA REPAIR (2014)
ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling
Rajashree A. Deshpande et al.
EMBO JOURNAL (2014)
Double-strand break repair: 53BP1 comes into focus
Stephanie Panier et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response
Yu-Fen Lin et al.
NUCLEIC ACIDS RESEARCH (2014)
Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System
Frederick W. Alt et al.
CELL (2013)
ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
Luis Ignacio Toledo et al.
CELL (2013)
To spread or not to spread - chromatin modifications in response to DNA damage
Matthias Altmeyer et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2013)
DNA-dependent Protein Kinase Regulates DNA End Resection in Concert with Mre11-Rad50-Nbs1 (MRN) and Ataxia Telangiectasia-mutated (ATM)
Yi Zhou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
DNA structure-specific priming of ATR activation by DNA-PKcs
Sophie Vidal-Eychenie et al.
JOURNAL OF CELL BIOLOGY (2013)
Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination
Baeck-Seung Lee et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
Activation of DSB Processing Requires Phosphorylation of CtIP by ATR
Shaun E. Peterson et al.
MOLECULAR CELL (2013)
Double strand break repair functions of histone H2AX
Ralph Scully et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2013)
被撤回的出版物: KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling (Retracted article. See vol. 568, pg. 576, 2019)
Abderrahmane Kaidi et al.
NATURE (2013)
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Yosef Shiloh et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
ATR Activates the S-M Checkpoint during Unperturbed Growth to Ensure Sufficient Replication Prior to Mitotic Onset
John Kenneth Eykelenboom et al.
CELL REPORTS (2013)
The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR-Mediated Double-Strand Break Repair
Hailong Wang et al.
PLOS GENETICS (2013)
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling
Abderrahmane Kaidi et al.
NATURE (2013)
A high-throughput, flow cytometry-based method to quantify DN-End resection in mammalian cells
Josep V. Forment et al.
CYTOMETRY PART A (2012)
Quantitative Live Cell Imaging Reveals a Gradual Shift between DNA Repair Mechanisms and a Maximal Use of HR in Mid S Phase
Ketki Karanam et al.
MOLECULAR CELL (2012)
Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
J. Ross Chapman et al.
MOLECULAR CELL (2012)
Double-Strand Break End Resection and Repair Pathway Choice
Lorraine S. Symington et al.
ANNUAL REVIEW OF GENETICS, VOL 45 (2011)
Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
Philip J. Stephens et al.
CELL (2011)
Factors determining DNA double-strand break repair pathway choice in G2 phase
Atsushi Shibata et al.
EMBO JOURNAL (2011)
Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase
Edward A. Nam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents
Jean-Damien Charrier et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation
Shizhou Liu et al.
MOLECULAR CELL (2011)
Role of ATM and the Damage Response Mediator Proteins 53BP1 and MDC1 in the Maintenance of G2/M Checkpoint Arrest
Atsushi Shibata et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
The DNA Damage Response: Making It Safe to Play with Knives
Alberto Ciccia et al.
MOLECULAR CELL (2010)
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
Emma Bolderson et al.
NUCLEIC ACIDS RESEARCH (2010)
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
Andrea Beucher et al.
EMBO JOURNAL (2009)
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells
Nozomi Tomimatsu et al.
EMBO REPORTS (2009)
Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes
Elsa Callen et al.
MOLECULAR CELL (2009)
The DNA-damage response in human biology and disease
Stephen P. Jackson et al.
NATURE (2009)
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
Yingli Sun et al.
NATURE CELL BIOLOGY (2009)
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
Daniel A. Mordes et al.
GENES & DEVELOPMENT (2008)
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
Martin F. Lavin
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
ATR: an essential regulator of genome integrity
Karlene A. Cimprich et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase
M. D. Rainey et al.
ONCOGENE (2008)
Human CtIP promotes DNA end resection
Alessandro A. Sartori et al.
NATURE (2007)
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction
Markus Loebrich et al.
NATURE REVIEWS CANCER (2007)
The Rad9-Hus1-Rad1 checkpoint interaction of TopBP1 with ATR
Joon Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
Shuhei Matsuoka et al.
SCIENCE (2007)
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break
Benjamin P. C. Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress
Hirohiko Yajima et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo
Manuela Pellegrini et al.
NATURE (2006)
Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex
KE Adams et al.
ONCOGENE (2006)
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
JS Myers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
TopBP1 activates the ATR-ATRIP complex
A Kumagai et al.
CELL (2006)
ATM regulates ATR chromatin loading in response to DNA double-strand breaks
M Cuadrado et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
A Jazayeri et al.
NATURE CELL BIOLOGY (2006)
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
TS Byun et al.
GENES & DEVELOPMENT (2005)
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
JH Lee et al.
SCIENCE (2005)
Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks
BPC Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
J Falck et al.
NATURE (2005)
Deficiency in the catalytic subunit of DNA-Dependent protein kinase causes down-regulation of ATM
YL Peng et al.
CANCER RESEARCH (2005)
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
JH Lee et al.
SCIENCE (2004)
Caffeine inhibits homology-directed repair of I-SceI-induced DNA double-strand breaks
HC Wang et al.
ONCOGENE (2004)
A pathway of double-strand break rejoining dependent upon ATM, artemis, and proteins locating to γ-H2AX foci
E Riballo et al.
MOLECULAR CELL (2004)
ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joining
HY Wang et al.
CANCER RESEARCH (2004)
Checking on DNA damage in S phase
J Bartek et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
DNA damage checkpoint control in cells exposed to ionizing radiation
G Iliakis et al.
ONCOGENE (2003)
An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells
X Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Pathways of DNA double-strand break repair during the mammalian cell cycle
K Rothkamm et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
L Zou et al.
SCIENCE (2003)
Chk1 and Chk2 kinases in checkpoint control and cancer
J Bartek et al.
CANCER CELL (2003)
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
CJ Bakkenist et al.
NATURE (2003)
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
RA DiTullio et al.
NATURE CELL BIOLOGY (2002)
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
H Takai et al.
EMBO JOURNAL (2002)
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
DW Chan et al.
GENES & DEVELOPMENT (2002)
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
A Hirao et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response
MT Jack et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Two molecularly distinct G2/M checkpoints are induced by ionizing irradiation
B Xu et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
ATR and ATRIP: Partners in checkpoint signaling
D Cortez et al.
SCIENCE (2001)
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
H Zhao et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DMA replication checkpoint
M Hekmat-Nejad et al.
CURRENT BIOLOGY (2000)
Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems
M Liu et al.
GENES & DEVELOPMENT (2000)
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
ZJ Guo et al.
GENES & DEVELOPMENT (2000)
Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1
R Melchionna et al.
NATURE CELL BIOLOGY (2000)
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
A de Klein et al.
CURRENT BIOLOGY (2000)
The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication
J Guan et al.
NUCLEIC ACIDS RESEARCH (2000)
分享论文
