期刊
SCIENTIFIC REPORTS
卷 9, 期 -, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/s41598-019-45235-7
关键词
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资金
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [804746]
- Danish Council for Independent Research (Sapere Aude) [4093-00280B]
- Vinnova
- VINNMER Marie Curie Industry Outgoing [2013-04350]
- Swedish Foundation for Strategic Research [AM13-0090, ITM17-0267]
- Swedish Research Council [2014-3910, 2018-03697]
- CONNECT network - Future and Emerging Technologies (FET) program within the Seventh Framework Program for Research of the European Commission, under FET-Open [23829]
- Cancer Research UK
- Engineering and Physical Sciences Research Council Cancer Imaging Centre in Cambridge and Manchester [C8742/A18097]
- Random Walk Imaging AB
- Swedish Research Council [2018-03697] Funding Source: Swedish Research Council
Characterization of porous media is essential in a wide range of biomedical and industrial applications. Microstructural features can be probed non-invasively by diffusion magnetic resonance imaging (dMRI). However, diffusion encoding in conventional dMRI may yield similar signatures for very different microstructures, which represents a significant limitation for disentangling individual microstructural features in heterogeneous materials. To solve this problem, we propose an augmented multidimensional diffusion encoding (MDE) framework, which unlocks a novel encoding dimension to assess time-dependent diffusion specific to structures with different microscopic anisotropies. Our approach relies on spectral analysis of complex but experimentally efficient MDE waveforms. Two independent contrasts to differentiate features such as cell shape and size can be generated directly by signal subtraction from only three types of measurements. Analytical calculations and simulations support our experimental observations. Proof-of-concept experiments were applied on samples with known and distinctly different microstructures. We further demonstrate substantially different contrasts in different tissue types of a post mortem brain. Our simultaneous assessment of restriction size and shape may be instrumental in studies of a wide range of porous materials, enable new insights into the microstructure of biological tissues or be of great value in diagnostics.
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