期刊
NUTRIENTS
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/nu11071664
关键词
lipotoxicity; kidney; uremia; skeletal muscle; sarcopenia
资金
- Japan Society for the Promotion of Science [18K08232, 15KT0088, 16K15465, 18H02727]
- Nakatomi Foundation
- Mitsui Sumitomo Insurance Welfare Foundation
- Kyowa Kirin Co. Ltd.
- Grants-in-Aid for Scientific Research [15KT0088, 18K08232, 16K15465] Funding Source: KAKEN
Dyslipidemia is a common nutritional and metabolic disorder in patients with chronic kidney disease. Accumulating evidence supports the hypothesis that prolonged metabolic imbalance of lipids leads to ectopic fat distribution in the peripheral organs (lipotoxicity), including the kidney, heart, and skeletal muscle, which accelerates peripheral inflammation and afflictions. Thus, lipotoxicity may partly explain progression of renal dysfunction and even extrarenal complications, including renal anemia, heart failure, and sarcopenia. Additionally, endoplasmic reticulum stress activated by the unfolded protein response pathway plays a pivotal role in lipotoxicity by modulating the expression of key enzymes in lipid synthesis and oxidation. Here, we review the molecular mechanisms underlying lipid deposition and resultant tissue damage in the kidney, heart, and skeletal muscle, with the goal of illuminating the nutritional aspects of these pathologies.
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