期刊
NUTRIENTS
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/nu11081752
关键词
added sugar; arterial stiffness; diabetes; epidemiology; adolescents and young adults
资金
- National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK077979]
- Centers for Disease Control and Prevention [00097, DP-05-069, DP-10-001]
- National Institute of Diabetes and Digestive and Kidney Diseases
- Kaiser Permanente Southern California [U48/CCU919219, U01 DP000246, U18DP002714]
- University of Colorado Denver [U48/CCU819241-3, U01 DP000247, U18DP000247-06A1]
- Children's Hospital Medical Center (Cincinnati) [U48/CCU519239, U01 DP000248, 1U18DP002709]
- University of North Carolina at Chapel Hill [U48/CCU419249, U01 DP000254, U18DP002708]
- University of Washington School of Medicine [U58/CCU019235-4, U01 DP000244, U18DP002710-01]
- Wake Forest University School of Medicine [U48/CCU919219, U01 DP000250, 200-2010-35171]
The relationship between added sugar and arterial stiffness in youth with type 1 diabetes (T1D) has not been well-described. We used data from the SEARCH for Diabetes in Youth Study (SEARCH), an ongoing observational cohort study, to determine the association between added sugar and arterial stiffness in individuals diagnosed with T1D <20 years of age (n = 1539; mean diabetes duration of 7.9 +/- 1.9 years). Added sugar intake was assessed by a food frequency questionnaire, and arterial stiffness measures included pulse wave velocity (PWV) and augmentation index. Separate multivariate linear regression models were used to evaluate the association between added sugar and arterial stiffness. Separate interaction terms were included to test for effect modification by body mass index (BMI) z-score and physical activity (PA). Overall, there was no association between added sugar and arterial stiffness (P > 0.05); however, the association between added sugar and arterial stiffness differed by BMI z-score (P for interaction = 0.003). For participants with lower BMI z-scores, added sugar intake was positively associated with PWV trunk measurements, whereas there was no association for those who had a higher BMI z-score. PA did not significantly modify the association between added sugar and arterial stiffness. Further research is needed to determine the longitudinal relationship and to confirm that obesity differentially affects this association.
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