期刊
NUTRIENTS
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/nu11061386
关键词
DASH; East Asian American; intermittent energy restriction; Mediterranean diet; randomized trial; total adiposity; visceral adipose tissue
资金
- National Cancer Institute at the National Institutes of Health [P01CA168530, P30 CA071789, U01CA164973]
- William & Ellen Melohn Endowed Research Fund, University of Hawaii
Intermittent energy restriction combined with a Mediterranean diet (IER+MED) has shown promise to reduce body fat and insulin resistance. In the Multiethnic Cohort Adiposity Phenotype Study, Japanese Americans had the highest visceral adipose tissue (VAT) when adjusting for total adiposity. We conducted this pilot study to demonstrate feasibility and explore efficacy of following IER+MED for 12 weeks to reduce VAT among East Asians in Hawaii. Sixty volunteers (aged 35-55, BMI 25-40 kg/m(2), VAT >= 90 cm(2) for men and >= 80 cm(2) for women) were randomized to IER+MED (two consecutive days with 70% energy restriction and 5 days euenergetic MED) or an active comparator (euenergetic Dietary Approaches to Stop Hypertension (DASH) diet). Participants and clinic staff (except dietitians) were blinded to group assignments. IER+MED had significantly larger reductions in DXA-measured VAT and total fat mass (-22.6 +/- 3.6 cm(2) and -3.3 +/- 0.4 kg, respectively) vs. DASH (-10.7 +/- 3.5 cm(2) and -1.6 +/- 0.4 kg) (p = 0.02 and p = 0.005). However, after adjusting for total fat mass, change in VAT was not statistically different between groups; whereas, improvement in alanine transaminase remained significantly greater for IER+MED vs. DASH (-16.2 +/- 3.8 U/L vs. -4.0 +/- 3.6 U/L, respectively, p = 0.02). Attrition rate was 10%, and participants adhered well to study prescriptions with no reported major adverse effect. Results demonstrate IER+MED is acceptable, lowers visceral and total adiposity among East Asian Americans, and may improve liver function more effectively than a healthful diet pattern. ClinicalTrials.gov Identifier: NCT03639350.
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