期刊
CURRENT PSYCHIATRY REPORTS
卷 21, 期 8, 页码 -出版社
SPRINGER
DOI: 10.1007/s11920-019-1048-6
关键词
Kraepelin; Dichotomy; Schizophrenia; Mood disorder; Bipolar
类别
Purpose of ReviewEmil Kraepelin, in 1899, proposed a dichotomy of psychiatric disorders into dementia praecox, further called schizophrenia, and manisch-depressives Irresein, now conceptualized as a bipolar disorder. The purpose of the review is to show both similarities and differences between disorders involved in this dichotomy, speaking for and against the idea.Recent FindingsOn the molecular genetic side, there are data for both a genetic overlap and genetic differences between these two illnesses. Among pharmacological treatment, lithium, valproates, and carbamazepine present evidence for Kraepelinian dichotomy while atypical antipsychotics speak against this. The recent results for similarities and differences in the immune system, cognitive functions, and neurodevelopmental mechanisms have also been presented and discussed.SummaryAs of 2019, the Kraepelinian dichotomy has been still partly valid although the results of recent clinical, neurobiological, and pharmacological studies provided a large number of data for an intermediate space between schizophrenia and bipolar disorder.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据