Optofluidic microcapillary biosensor for label free, low glucose concentration detection

We demonstrate label-free detection of low glucose concentration based on whispery gallery mode resonance in an optofluidic microcapillary (OFMC) biosensor. The wall surface of the OFMC is bio-chemically functionalized to detect cellular-level glucose concentration as low as 2.78 mM. The measured sensitivity is 0.966 pm/mM. The fabricated microcapillary has a thin wall thickness of 2 tun and a Q factor of 1.3 x 10(6), corresponding to a bulk refractive index sensitivity of 23.36 nm/RIU. The OFMC biosensor has advantages such as high resistance to environmental perturbation. small sample volume down to 90 nL and cost-effectiveness. Theoretical analysis shows the sensor sensitivity depends on the microcapillary wall thickness and liquid core refractive index. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement