期刊
ACS COMBINATORIAL SCIENCE
卷 21, 期 8, 页码 568-572出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.9b00096
关键词
Ritter reaction; solid-phase synthesis; triazenes; amide formation; pyrazoles
资金
- Helmholtz program Biolnterfaces in Technology and Medicine (BIFTM)
- Deutsche Forschungsgemeinschaft [BR1750/40-1, JU2909/5-1]
- DFG [BR1750/34-1]
A novel route for the synthesis of N-arylamides via the cleavage of aryltriazenes with alkyl or aryl nitriles is presented. We developed a variation of the Ritter reaction that allows the use of acetonitrile as solvent and reagent in reactions with solid-supported precursors. The reaction was optimized for the generation of N-aryl acetamides using a diverse range of immobilized building blocks including o-, m-, and p-substituted aryltriazenes. The cleavage via the Ritter-type reaction of halogen-substituted aryltriazenes with pyrazoles. Additionally, the synthesis conversion was combined with an on-bead cross-coupling of on-bead generated arylboronic ester substituted triazenes was shown. The developed procedure was further expanded to use other commercially available nitriles, such as acrylonitrile, benzonitrile, and chlorinated alkyl nitriles as suitable reagents for a Ritter-type cleavage of the prepared triazene linkers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据