4.8 Article

Harnessing the Elusive 1,4-Reduction of Vinyl Epoxides through Copper Catalysis

期刊

ACS CATALYSIS
卷 9, 期 7, 页码 6583-6587

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b02005

关键词

vinyl epoxides; borylation; copper catalysis; allylic alcohols; skipped dienes

资金

  1. European Research Council [ERC-337776]
  2. MINECO [CTQ2016-78779-R]

向作者/读者索取更多资源

We present an efficient strategy for the formal 1,4-reduction of vinyl epoxides that does not require superstoichiometric amounts of a strong reductant. Using a readily available copper catalyst and a diboron compound, a wide variety of enantioenriched allylic alcohols have been prepared. Additionally, epoxyenynes have been reduced in a 1,4-manner to selectively afford skipped enynes or skipped dienes.

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