期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-019-09576-1
关键词
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资金
- Medical Research Council [MR/M005070/1, 9072, 16434]
- EC Horizon2020 [MR/M005070/1, LIFEPATH 633666]
- Diabetes Research and Wellness Foundation Fellowship [LIFEPATH 633666]
- Wellcome Trust Institutional Strategic Support Award [WT097835MF]
- European Research Council
- Diabetes UK RD Lawrence fellowship [SZ-245 50371-GLUCOSEGENES-FP7-IDEAS-ERC, 323195]
- Wellcome Trust [17/0005594]
- Royal Society [104150/Z/14/Z.K.S.R.]
- Gillings Family Foundation - NIH
- Erasmus MC, Rotterdam, The Netherlands [1R01HL143790-01]
- Netherlands Organisation of Scientific Research NWO Investments [175.010.2005.011, 911-03-012]
- Genetic Laboratory of the Department of Internal Medicine, Erasmus MC
- Research Institute for Diseases in the Elderly [014-93-015]
- Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) Netherlands Consortium for Healthy Aging (NCHA)
- Erasmus Medical Centre [050-060-810]
- Netherlands Organisation for the Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly (RIDE)
- Ministry of Education, Culture and Science
- Ministry for Health, Welfare and Sports, the European Commission (DG XII)
- Municipality of Rotterdam [MEC 02.1015]
- Dutch Ministry of Health, Welfare and Sport
- GlaxoSmithKline [1071272-159521-PG, NTR6831]
- Faculty of Biology and Medicine of Lausanne
- Swiss National Science Foundation [33CSCO-122661, 33CS30-139468, 33CS30-148401]
- Ethics Commission of Canton Vaud
- US National Institutes on Aging [16/03, 33/09, 26/14, PB_2018-00040]
- UK Medical Research Council [R01AG013196, R01AG034454]
- British Heart Foundation [MRC K013351, MR/R024227/1]
- University College London Hospital Committee on the Ethics of Human Research [RG/13/2/30098]
- [85/0938]
- MRC [MR/S011676/1, MR/R024227/1, MR/M005070/1, MR/P012167/1] Funding Source: UKRI
Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing sleep quality, quantity and timing, and validate our findings in 5,819 individuals. We identify 47 genetic associations at P < 5 x 10(-8), of which 20 reach a stricter threshold of P < 8 x 10(-10). These include 26 novel associations with measures of sleep quality and 10 with nocturnal sleep duration. The majority of identified variants associate with a single sleep trait, except for variants previously associated with restless legs syndrome. For sleep duration we identify a missense variant (p.Tyr727Cys) in PDE11A as the likely causal variant. As a group, sleep quality loci are enriched for serotonin processing genes. Although accelerometer-derived measures of sleep are imperfect and may be affected by restless legs syndrome, these findings provide new biological insights into sleep compared to previous efforts based on self-report sleep measures.
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