期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-10467-8
关键词
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资金
- Finnish Cultural Foundation (Suomen Kulttuurirahasto) [00161034]
- Academy of Finland [276523, 288220]
- Sigrid Juselius Foundation (Sigrid Juseliuksen Saatio)
- Finnish Pediatric Foundation (Lastentautien tutkimussaatio)
- Australian National Health and Medical Research Council [1144936, 1145168, 1136649, 1037196, 1099082, 1138711]
- Rebecca L. Cooper Foundation [PG2018109]
- Australian Research Council Centre of Excellence for Integrative Brain Function [CE140100007]
- National Health and Medical Research Council of Australia [1099082, 1144936, 1145168] Funding Source: NHMRC
Sleep architecture carries vital information about brain health across the lifespan. In particular, the ability to express distinct vigilance states is a key physiological marker of neurological wellbeing in the newborn infant although systems-level mechanisms remain elusive. Here, we demonstrate that the transition from quiet to active sleep in newborn infants is marked by a substantial reorganization of large-scale cortical activity and functional brain networks. This reorganization is attenuated in preterm infants and predicts visual performance at two years. We find a striking match between these empirical effects and a computational model of large-scale brain states which uncovers fundamental biophysical mechanisms not evident from inspection of the data. Active sleep is defined by reduced energy in a uniform mode of neural activity and increased energy in two more complex anteroposterior modes. Preterm-born infants show a deficit in this sleep-related reorganization of modal energy that carries novel prognostic information.
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