期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-019-11162-4
关键词
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资金
- National Key Basic Research Program of China (973 Program) [2015CB553905]
- National Natural Science Foundation of China [81402278, 81472175, 81772461, 81702838]
- Shanghai Natural Science Foundation of China [16ZR1434700]
- Shanghai Municipal Commission of Health and Family Planning [201640055, 201640007, 20134007]
- Medical Guidance Project of Shanghai Science and Technology Committee [15411961500]
- State Key Laboratory of Oncogenes and Related Gene [91-17-12]
Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown. Herein, we explore the expression profiles of circRNA and mRNA in 5 paired samples of LUSC. By analyzing the co-expression network of differentially expressed circRNAs and dysregulated mRNAs, we identify that a cell cycle-related circRNA, circTP63, is upregulated in LUSC tissues and its upregulation is correlated with larger tumor size and higher TNM stage in LUSC patients. Elevated circTP63 promotes cell proliferation both in vitro and in vivo. Mechanistically, circTP63 shares miRNA response elements with FOXM1. circTP63 competitively binds to miR-873-3p and prevents miR-873-3p to decrease the level of FOXM1, which upregulates CENPA and CENPB, and finally facilitates cell cycle progression.
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