期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-019-10659-2
关键词
-
资金
- NIH [AI114235, AI117841, AI120008, AI130005, AI122377, AI124776, AI135940, DA047034, HL134539, AI116228]
- Bill and Melinda Gates Foundation [OPP1066973, OPP1146433]
- Gilead Sciences, Inc. [00406]
- International AIDS Vaccine Initiative (IAVI) [UKZNRSA1001]
- NIAID [R37AI067073]
- Witten Family Foundation
- Dan and Marjorie Sullivan Foundation
- Mark and Lisa Schwartz Foundation
- AIDS Healthcare Foundation
- Harvard University Center for AIDS Research (CFAR - US National Institutes of Health: NIAID) [P30 AI060354]
- Harvard University Center for AIDS Research (CFAR - US National Institutes of Health: NCI) [P30 AI060354]
- Harvard University Center for AIDS Research (CFAR - US National Institutes of Health: NICHD) [P30 AI060354]
- Harvard University Center for AIDS Research (CFAR - US National Institutes of Health: NHLBI) [P30 AI060354]
- Harvard University Center for AIDS Research (CFAR - US National Institutes of Health: NIDA) [P30 AI060354]
- Harvard University Center for AIDS Research (CFAR - US National Institutes of Health: NIMH) [P30 AI060354]
- Harvard University Center for AIDS Research (CFAR - US National Institutes of Health: NIA) [P30 AI060354]
- Harvard University Center for AIDS Research (CFAR - US National Institutes of Health: FIC) [P30 AI060354]
- Harvard University Center for AIDS Research (CFAR - US National Institutes of Health: OAR) [P30 AI060354]
- Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE), a DELTAS Africa Initiative [DEL-15-006]
- New Partnership for Africa's Development Planning and Coordinating Agency (NEPAD Agency)
- Wellcome Trust [107752/Z/15/Z]
- United Kingdom (UK) government
- Bill and Melinda Gates Foundation [OPP1146433, OPP1066973] Funding Source: Bill and Melinda Gates Foundation
Little is known about the genotypic make-up of HIV-1 DNA genomes during the earliest stages of HIV-1 infection. Here, we use near-full-length, single genome next-generation sequencing to longitudinally genotype and quantify subtype C HIV-1 DNA in four women identified during acute HIV-1 infection in Durban, South Africa, through twice-weekly screening of high-risk participants. In contrast to chronically HIV-1-infected patients, we found that at the earliest phases of infection in these four participants, the majority of viral DNA genomes are intact, lack APOBEC-3G/F-associated hypermutations, have limited genome truncations, and over one year show little indication of cytotoxic T cell-driven immune selections. Viral sequence divergence during acute infection is predominantly fueled by single-base substitutions and is limited by treatment initiation during the earliest stages of disease. Our observations provide rare longitudinal insights of HIV-1 DNA sequence profiles during the first year of infection to inform future HIV cure research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据