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Zhe Ma et al.
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Qiang Wang et al.
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Takayuki Abe et al.
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Veit Hornung et al.
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Pu Gao et al.
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Xu Zhang et al.
MOLECULAR CELL (2013)
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Andrea Ablasser et al.
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Jeonghyun Ahn et al.
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Roman Barbalat et al.
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S. Mehdi Belgnaoui et al.
CURRENT OPINION IN IMMUNOLOGY (2011)
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PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
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New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
Jonathan B. Baell et al.
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Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
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Hiroki Ishikawa et al.
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Bo Zhong et al.
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Phaser crystallographic software
Airlie J. McCoy et al.
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Yanick J. Crow et al.
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M Koresawa et al.
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A Bender et al.
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UCSF chimera - A visualization system for exploratory research and analysis
EF Pettersen et al.
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