期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 10, 期 7, 页码 1026-1032出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.9b00149
关键词
Peptides; macrocyclization; cell permeability; intramolecular hydrogen bond networks; cyclotides
Macrocycles have emerged as a viable approach for the modulation of tough targets in drug discovery. In this Innovations article we discuss recent progress toward the design of cell permeable and orally bioavailable peptide macrocycles and cyclotides and provide a perspective for their potential as therapeutics. We highlight design concepts that may be broadly relevant to drug discovery efforts beyond the rule of five.
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