相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)
Ying Jiang et al.
JOURNAL OF NEUROSCIENCE (2019)
Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
Sarah Pickles et al.
CURRENT BIOLOGY (2018)
mTOR in Down syndrome: Role in A beta and tau neuropathology and transition to Alzheimer disease-like dementia
Fabio Di Domenico et al.
FREE RADICAL BIOLOGY AND MEDICINE (2018)
Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
Karen Frudd et al.
NATURE COMMUNICATIONS (2018)
FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway
Wen Li et al.
ENDOCRINOLOGY (2017)
Characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling by integrative analysis of transcriptomic and proteomic data
Jiheon Shin et al.
SCIENTIFIC REPORTS (2017)
Molecular definitions of autophagy and related processes
Lorenzo Galluzzi et al.
EMBO JOURNAL (2017)
Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy
Matteo Bordi et al.
AUTOPHAGY (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky et al.
AUTOPHAGY (2016)
Mitochondrial Cristae: Where Beauty Meets Functionality
Sara Cogliati et al.
TRENDS IN BIOCHEMICAL SCIENCES (2016)
Down syndrome and Alzheimer's disease: Common pathways, common goals
Dean Hartley et al.
ALZHEIMERS & DEMENTIA (2015)
The mitochondrial voltage-dependent anion channel 1 in tumor cells
Varda Shoshan-Barmatz et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2015)
Autophagy machinery in the context of mammalian mitophagy
Saori R. Yoshii et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)
MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5
Catherine L. Nezich et al.
JOURNAL OF CELL BIOLOGY (2015)
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Michael Lazarou et al.
NATURE (2015)
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson's Disease
Alicia M. Pickrell et al.
NEURON (2015)
limma powers differential expression analyses for RNA-sequencing and microarray studies
Matthew E. Ritchie et al.
NUCLEIC ACIDS RESEARCH (2015)
Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy
Giulia Milan et al.
NATURE COMMUNICATIONS (2015)
Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
Ju-Hyun Lee et al.
CELL REPORTS (2015)
Decreased cell proliferation and higher oxidative stress in fibroblasts from Down Syndrome fetuses. Preliminary study
Amparo Gimeno et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain
Marzia Perluigi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis
Jose A. Martina et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2014)
ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy
Wenxian Wu et al.
EMBO REPORTS (2014)
mTOR Hyperactivation in Down Syndrome Hippocampus Appears Early During Development
Anand M. Iyer et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2014)
Domains of genome-wide gene expression dysregulation in Down's syndrome
Audrey Letourneau et al.
NATURE (2014)
Ubiquitin is phosphorylated by PINK1 to activate parkin
Fumika Koyano et al.
NATURE (2014)
Making new contacts: the mTOR network in metabolism and signalling crosstalk
Mitsugu Shimobayashi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression
Ruben Gomez-Sanchez et al.
NEUROBIOLOGY OF DISEASE (2014)
Epigenetics: The neglected key to minimize learning and memory deficits in Down syndrome
Alain D. Dekker et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2014)
Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy
Rachael M. Ivatt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
Yvette C. Wong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Regulation of mTORC1 by amino acids
Liron Bar-Peled et al.
TRENDS IN CELL BIOLOGY (2014)
FOXO Transcription Factors: Their Clinical Significance and Regulation
Yu Wang et al.
BIOMED RESEARCH INTERNATIONAL (2014)
After the banquet Mitochondrial biogenesis, mitophagy, and cell survival
Jianhui Zhu et al.
AUTOPHAGY (2013)
The pathways of mitophagy for quality control and clearance of mitochondria
G. Ashrafi et al.
CELL DEATH AND DIFFERENTIATION (2013)
Adaptive Downregulation of Mitochondrial Function in Down Syndrome
Pablo Helguera et al.
CELL METABOLISM (2013)
SOD2 in mitochondrial dysfunction and neurodegeneration
James M. Flynn et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
Chronic pro-oxidative state and mitochondrial dysfunctions are more pronounced in fibroblasts from Down syndrome foeti with congenital heart defects
Claudia Piccoli et al.
HUMAN MOLECULAR GENETICS (2013)
Phosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent Ubiquitination of Endogenous Parkin Attenuates Mitophagy STUDY IN HUMAN PRIMARY FIBROBLASTS AND INDUCED PLURIPOTENT STEM CELL-DERIVED NEURONS
Aleksandar Rakovic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Regulation of mTORC1 and its impact on gene expression at a glance
Mathieu Laplante et al.
JOURNAL OF CELL SCIENCE (2013)
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
Francesca Nazio et al.
NATURE CELL BIOLOGY (2013)
Emerging regulation and functions of autophagy
Patricia Boya et al.
NATURE CELL BIOLOGY (2013)
The role of autophagy in neurodegenerative disease
Ralph A. Nixon
NATURE MEDICINE (2013)
The autophagosome: origins unknown, biogenesis complex
Christopher A. Lamb et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
Carmine Settembre et al.
EMBO JOURNAL (2012)
Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
Eisuke Itakura et al.
JOURNAL OF CELL SCIENCE (2012)
Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway
Daniela Valenti et al.
BIOCHEMICAL JOURNAL (2011)
The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage
D. De Zio et al.
CELL DEATH AND DIFFERENTIATION (2011)
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
L. Bouman et al.
CELL DEATH AND DIFFERENTIATION (2011)
An Increase in Basal BDNF Provokes Hyperactivation of the Akt-Mammalian Target of Rapamycin Pathway and Deregulation of Local Dendritic Translation in a Mouse Model of Down's Syndrome
Jose Antonio Troca-Marin et al.
JOURNAL OF NEUROSCIENCE (2011)
Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation
Fanjun Meng et al.
MOLECULAR NEURODEGENERATION (2011)
Rapamycin passes the torch: a new generation of mTOR inhibitors
Don Benjamin et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan et al.
SCIENCE (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
Carmine Settembre et al.
SCIENCE (2011)
ROAST: rotation gene set tests for complex microarray experiments
Di Wu et al.
BIOINFORMATICS (2010)
AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity
Christine M. Chresta et al.
CANCER RESEARCH (2010)
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
Ying Zhao et al.
NATURE CELL BIOLOGY (2010)
FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation
Yang Mei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The effects of oxidative stress on parkin and other E3 ligases
Matthew J. LaVoie et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome
Ebrahim Abdul Shukkur et al.
HUMAN MOLECULAR GENETICS (2006)
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
A Subramanian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators
N Gleyzer et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Altered metabolism of the amyloid β precursor protein is associated with mitochondrial dysfunction in Down's syndrome
J Busciglio et al.
NEURON (2002)
The DNA sequence of human chromosome 21
M Hattori et al.
NATURE (2000)