期刊
JOURNAL OF FUNCTIONAL FOODS
卷 58, 期 -, 页码 189-198出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2019.04.062
关键词
Melatonin; Influenza A virus; Pneumonia; TNF-alpha; IL-10; IL-27
资金
- Ministry of Science and Technology, Taiwan [MOST-106-2320-B-016-014, MOST-107-2314-B-016-006, MOST-106-2314-B-016-045]
- Tri-Service General Hospital, Taiwan [TSGH-C105-015, TSGH-C106-015]
- Ministry of National Defense-Medical Affairs Bureau, Taiwan [MAB-107-029, MAB-107-033]
- Taoyuan Armed Forces General Hospital, Taiwan [AFTYGH-10425]
Influenza is an infectious disease caused by an RNA virus that affects birds and mammals. It is a leading cause of morbidity, mortality and economic loss worldwide. Under influenza A virus infection, an uncontrolled inflammatory response in the lungs frequently leads to severe pneumonia. The anti-inflammatory and immune modulatory effects of melatonin may provide a beneficial effect for this disease. In this study, we found that melatonin treatment significantly decreases the expression of TNF-alpha, IL-6 and IFN-gamma and increases the production of IL-10 and TGF-beta. The induction of IL-10 by melatonin occurs via the upregulation of IL-27 expression in dendritic cells. Melatonin also significantly inhibits the production of TNF-alpha in CD8 T cells. Co-treatment of melatonin and ribavirin significantly increases the survival of virus-infected mice compared to ribavirin alone. Our study suggests that melatonin possesses a therapeutic potential in influenza-induced pneumonia as an adjuvant treatment with anti-viral drugs.
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