期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 45, 期 10, 页码 2612-2622出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2019.06.421
关键词
Conventional US; 2-D shear wave elastography; Virtual touch tissue imaging quantification; Immunohistochemical subtypes; Breast cancer
资金
- Fundamental Research Funds for the Central Universities of China [22120180381]
Our study aimed to investigate the correlation of the imaging features obtained using conventional ultrasound (US) and elastography (conventional strain elastography of elasticity imaging [EI], virtual touch tissue imaging [VTI] and 2-D shear wave elastography [2-D-SWE] of virtual touch tissue imaging quantification [VTIQ]) with the clinicopathologic features and immunohistochemical (IHC) subtypes of breast cancer. The sample consisted of images from 202 patients with 206 breast lesions that were confirmed as breast cancers. Lesions with HER2 overexpression (luminal B HER2+ or HER2+) had higher mean shear wave velocity (SWV) values than the others. Older patients, lower histologic grade, no lymphovascular invasion and no lymph node metastasis were associated with luminal A (p < 0.001). There were significant differences in SWV values, histologic grade and lymph node status among the different pathologic types. This association may allow the use of 2-D-SWE in the pre-operative prediction of tumor characteristics and biologic activity, which may determine the prognosis in a non-invasive manner. (C) 2019 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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