期刊
TRENDS IN MOLECULAR MEDICINE
卷 25, 期 10, 页码 853-865出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2019.05.011
关键词
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资金
- Portuguese Foundation for Science and Technology (FCT)
- FEDER, Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020, Operational Programme for Competitiveness and Internationalization (POCI), Portugal 2020
- Portuguese funds through FCT, Foundation for Science and Technology/Ministerio da Ciencia, Tecnologia e Inovacao [POCI-01-0145-FEDER-007274, PEst-C/SAU/LA0003/2013]
- Norte Portugal Regional Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) [NORTE-010145-FEDER-000029]
- Aveiro Institute of Biomedicine, iBiMED - FCT [UID/BIM/04501/2013]
- Ilidio Pinho Foundation
- University of Aveiro
- FCT/FEDER [PTDC/MED-ONC/28834/2017, PTDC/BIA-MIB/31238/2017]
- Centro 2020 program [CENTRO-01-0145-FEDER-000003]
- Portugal 2020 [CENTRO-01-0145-FEDER-000003]
- European Regional Development Fund [CENTRO-01-0145-FEDER-000003]
- Fundação para a Ciência e a Tecnologia [PTDC/MED-ONC/28834/2017, PTDC/BIA-MIB/31238/2017, PEst-C/SAU/LA0003/2013] Funding Source: FCT
The expression of transfer RNAs (tRNAs) is deregulated in cancer cells but the mechanisms and functional meaning of such deregulation are poorly understood. The proteome of cancer cells is not fully encoded by their transcriptome, however, the contribution of mRNA translation to suci diversity remains to be elucidated. We review data supporting the hypothesis that tRNA expression deregulation and translational error rate is an important contributor to proteome diversity and cell population heterogeneity, genome instability, and drug resistance in tumors. This by pothesis is aligned with recent data in various model organisms, showing unanticipated adaptive roles of translational errors (adaptive mistranslation), expression control of specific gene subsets by tRNAs, and proteome diversification by elevation of translational error rates in tumors.
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