期刊
TRENDS IN MICROBIOLOGY
卷 27, 期 9, 页码 792-805出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2019.05.007
关键词
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资金
- National Natural Science Foundation of China [31720103914]
- Central Public-interest Scientific Institution Basal Research Fund of China [S2019XM16]
- Youth Talent Program of Chinese Academy of Agricultural Sciences
- AAFC
- Natural Sciences and Engineering Research Council of Canada (NSERC)
RNA silencing is a fundamental, evolutionarily conserved mechanism that regulates gene expression in eukaryotes. It also functions as a primary immune defense in microbes, such as viruses in plants. In addition to RNA silencing, RNA decay and RNA quality-control pathways are also two ancestral forms of intrinsic antiviral immunity, and the three RNA-targeted pathways may operate cooperatively for their antiviral function. Plant viruses encode viral suppressors of RNA silencing (VSRs) to suppress RNA silencing and facilitate virus infection. In response, plants may activate a counter-counter-defense mechanism to cope with VSR-mediated RNA silencing suppression. In this review, we summarize current knowledge of RNA silencing, RNA decay, and RNA quality control in antiviral defense, and highlight the mechanisms by which viruses compromise RNA-targeted immunity for their infection and survival in plants.
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