期刊
TRENDS IN MICROBIOLOGY
卷 27, 期 10, 页码 824-835出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2019.05.006
关键词
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资金
- South Africa National Research Foundation [CPRR160421162721]
- Rosenkranz Prize
- Stanford Center for Innovation in Global Health seed award
- Fogarty Global Health Equity Scholar award [TW009338]
- Center for Computational, Evolutionary and Human Genomics
- Stanford MedScholars program
Descriptive and translational investigations into the human gut microbiome (GM) are rapidly expanding; however, studies are largely restricted to industrialized populations in the USA and Europe. Little is known about microbial variability and its implications for health and disease in other parts of the world. Populations in Africa are particularly underrepresented. What limited research has been performed has focused on a few subject domains, including the impact of long-term lifestyle and dietary factors on GM ecology, its maturation during infancy, and the interrelationships between the microbiome, infectious disease, and undernutrition. Recently, international consortia have laid the groundwork for large-scale genomics and microbiome studies on the continent, with a particular interest in the epidemiologic transition to noncommunicable disease. Here, we survey the current landscape of GM scholarship in Africa and propose actionable recommendations to improve research capacity and output.
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